Chapter 7 Specimen Collection and Processing Doris M. Haverstick, Ph.D., D.A.B.C.C. and Amy R. Groszbach, M.E.D., M.L.T., M.B.(A.S.C.P.)C.M.* Proper collection, identification, processing, storage, and transport of common sample types associated…
Chapter 38 Genomes and Nucleic Acid Alterations Carl T. Wittwer, M.D., Ph.D. and Noriko Kusukawa, Ph.D. Molecular diagnostics focuses on medically important sequence variations within a background of complex genomic…
Chapter 45 Plasma Nucleic Acids Y.M. Dennis Lo, M.A., D.M., D.Phil., F.R.C.P.(Lond. & Edin.), F.R.C.Path., F.R.S., and Rossa W.K. Chiu, M.B.B.S., Ph.D., F.H.K.A.M.(Pathology), F.R.C.P.A. With the notable exception of virology,…
Chapter 23 Enzymes of the Red Blood Cell Wouter W. van Solinge, Ph.D. and Richard van Wijk, Ph.D. Erythrocytes perform a variety of functions, the most important being the binding,…
Chapter 39 Nucleic Acid Isolation Rossa W.K. Chiu, M.B.B.S., Ph.D., F.H.K.A.M.(Pathology), F.R.C.P.A. and Y.M. Dennis Lo, M.A., D.M., D.Phil., F.R.C.P.,(Lond. & Edin.), F.R.C.Path., F.R.S.* Many of the key advances in…
Chapter 19 Automation in the Clinical Laboratory James C. Boyd, M.D. and Charles D. Hawker, Ph.D., M.B.A., F.A.C.B. The term automation has been applied in clinical chemistry to describe the…
Chapter 1 Clinical Chemistry, Molecular Diagnostics, and Laboratory Medicine David E. Bruns, M.D., Edward R. Ashwood, M.D. and Carl A. Burtis, Ph.D. Clinical chemists, clinical biochemists, chemical pathologists, medical technologists,…
Figure 16-1 Pedigree of a family with an autosomal recessive condition. The probability of being a carrier is shown beneath each individual symbol in the pedigree. In contrast to single-gene disorders, the…
Figure 10-1 The effect of recombination on the origin of various portions of a chromosome. Because of crossing over in meiosis, the copy of the chromosome the boy (generation III) inherited from…
Fortunately, the factorial terms are always the same in the numerator and denominator of the likelihood ratio, and therefore they cancel each other out and can be ignored. If θ…
