PHARMACY

Hard Shell Capsule Filling Machines

Dec 8, 2017 by in PHARMACY Comments Off on Hard Shell Capsule Filling Machines

Figure 6.1Basic operations common to all filling machines. (Courtesy of IMA ACTIVE division, Bologna, Italy.) Separation The diameter of the upper bushing or housing is larger than the diameter of…

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Modeling Powder Filling during Encapsulation

Dec 8, 2017 by in PHARMACY Comments Off on Modeling Powder Filling during Encapsulation

Figure 10.1Capsules produced from two encapsulation methods: (a) manual filling (loose powder); (b) automatic machine (plug). Machines having five tamping stations (Bosch GKF and Höfliger-Karg machines) compress the powder once…

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Plug Formation

Dec 8, 2017 by in PHARMACY Comments Off on Plug Formation

Figure 9.1(a) Schematic drawing of a force–time profile that would be obtained on an eccentric tablet press, based on time calculations for a running speed of 43.6 rpm66 and general…

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Quality-by-Design (QbD) for Capsule Formulation and Process DevelopmentRegulatory Science Relevance, Scientific Case Studies, and Future Challenges

Dec 8, 2017 by in PHARMACY Comments Off on Quality-by-Design (QbD) for Capsule Formulation and Process DevelopmentRegulatory Science Relevance, Scientific Case Studies, and Future Challenges

Figure 15.1ASTM D 6940-04 Segregation tester (with the top slide gate open and the powder flow from the mass flow hopper down to the funnel flow hopper). Fifty-milliliter glass beakers…

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Hard Shell Capsules in Clinical Trials

Dec 8, 2017 by in PHARMACY Comments Off on Hard Shell Capsules in Clinical Trials

Figure 3.1PCcaps overall length and dimensions showing locking ring. (Courtesy of Capsugel.) Shen and Zhong [5] studied the bioavailability of atorvastatin in beagle dogs using SMEDDS consisting excipients such as…

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Capsule Shell Manufacture

Dec 8, 2017 by in PHARMACY Comments Off on Capsule Shell Manufacture

Figure 4.1Photograph of the Technophar capsule manufacturing machine. Hard capsule shell manufacturing remained almost exclusively in the United States from the 1880s until after the Second World War. Eli Lilly…

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Non-Gelatin-Based Capsules

Dec 8, 2017 by in PHARMACY Comments Off on Non-Gelatin-Based Capsules

Figure 5.1Sorption isotherm data (absorption and desorption) of gelatin and HPMC (Vcaps® Plus) capsules stored at different RH values. (Courtesy of Capsugel.) The mechanical resistance and stiffness of two-piece capsules…

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Analytical Testing and Evaluation of Capsules

Dec 8, 2017 by in PHARMACY Comments Off on Analytical Testing and Evaluation of Capsules

Figure 13.1Equilibrium moisture content of empty gelatin capsule shells stored at different relative humidities for 2 weeks at 20°C. (Reprinted from Adv Drug Del Rev, 60, Cole ET, Cade D,…

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