Coagulation Disorders

Oct 29, 2016 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Coagulation Disorders

Figure 15.1 The Coagulation Cascade: a activated factor; Ca 2+ calcium; PL phospholipid. Reprinted with permission from Davie EW, Fujikawa K, Kisiel W. The coagulation cascade: initiation, maintenance and regulation….

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Molecular HLA Typing

Oct 29, 2016 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Molecular HLA Typing

Name Molecular characteristics HLA-F Class I-like molecule HLA-G Class I-like molecule HLA-H Class I pseudogene HLA-A Class I α chain HLA-J Class I pseudogene HLA-E Class I-like molecule HLA-C Class…

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T-Cell Lymphomas

Oct 29, 2016 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on T-Cell Lymphomas

T-cell prolymphocytic leukemia T-cell large granular lymphocytic leukemia Chronic lymphoproliferative disorders of NK cells Aggressive NK-cell leukemia Epstein-Barr virus (EBV) positive T-cell lymphoproliferative disorders of childhood  Systemic EBV-positive T-cell lymphoproliferative…

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Prostate Cancer

Oct 29, 2016 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Prostate Cancer

Change Gene Encodes Location Function Tumor Suppressor Genes NKX3.1 Prostate restricted homeobox protein 8p21.2 Suppresses cell proliferation PTEN Phosphatase and tensin homolog 10q23.31 Suppresses cell proliferation and increases apoptosis CDKN1B…

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Colorectal Cancer

Oct 29, 2016 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Colorectal Cancer

Pathway Genes Frequency (%) MAPK pathway KRAS 40–45  NRAS 2.5  BRAF 5–10 PI3K pathway PIK3CA 15  PTEN 10–20  AKT 5 Table 31.2 Overall RAS mutations in CRCs without mutations in…

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