Model Building

Jun 21, 2016 by in PHARMACY Comments Off on Model Building

Chapter 5Model Building: Typical Process 5.1 Introduction Owing to the hierarchical nature of population pharmacokinetic/pharmacodynamic (PK/PD) nonlinear mixed effect models as well as the typical complexity of such model development…

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NONMEM Overview and Writing an NM-TRAN Control Stream

Jun 21, 2016 by in PHARMACY Comments Off on NONMEM Overview and Writing an NM-TRAN Control Stream

Chapter 3NONMEM Overview and Writing an NM-TRAN Control Stream 3.1 Introduction After describing the main components of the NONMEM system, this chapter will provide a detailed explanation of the essential…

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Population Model Concepts and Terminology

Jun 21, 2016 by in PHARMACY Comments Off on Population Model Concepts and Terminology

Chapter 2 Population Model Concepts and Terminology 2.1 Introduction Pharmacometrics is a science that employs mathematical models in diverse applications of the pharmaceutical sciences. These models are used to concisely…

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User-Written Models

Jun 21, 2016 by in PHARMACY Comments Off on User-Written Models

Chapter 9User-Written Models 9.1 Introduction Nonlinear mixed effect models are useful for the construction of an immense variety of pharmacometric models. The PRED and PREDPP routines of NONMEM provide flexibility…

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Interpreting the NONMEM Output

Jun 21, 2016 by in PHARMACY Comments Off on Interpreting the NONMEM Output

Chapter 6 Interpreting the NONMEM Output 6.1 Introduction The appropriate interpretation of the output from NONMEM may well be considered the art in what is often referred to as the…

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PK/PD Models

Jun 21, 2016 by in PHARMACY Comments Off on PK/PD Models

Chapter 10PK/PD Models 10.1 Introduction Most of the discussion up to this point in our text has been in regard to pharmacokinetics (PK) alone. However, PK considerations in the development…

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The Practice of Pharmacometrics

Jun 21, 2016 by in PHARMACY Comments Off on The Practice of Pharmacometrics

Chapter 1The Practice of Pharmacometrics 1.1 Introduction In the course of the development and clinical use of pharmaceutical products, many questions arise that require quantitative answers regarding issues of safety…

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