Chapter 44 Hematopoietic Malignancies Kojo S.J. Elenitoba-Johnson, M.D. The hematologic malignancies include leukemias, lymphomas, myeloproliferative disorders, and plasma cell neoplasia. The leukemias are primarily bone marrow and peripheral blood–based processes,…
Chapter 21 Amino Acids, Peptides, and Proteins Glen L. Hortin, M.D., Ph.D* Amino acids, peptides, and proteins are crucial for virtually all biological processes. Amino acids have diverse roles in…
Chapter 53 Pituitary Function and Pathophysiology William E. Winter, M.D., Ishwarlal Jialal, M.D., Ph.D., F.R.C.Path(London), D.A.B.C.C., Mary Lee Vance, M.D. and Roger L. Bertholf, Ph.D.* The pituitary gland (also called…
Chapter 43 Pharmacogenetics Gwendolyn A. McMillin, Ph.D., D.A.B.C.C.(C.C., T.C.)* The term pharmacogenetics comes from merging the names of pharmacology (the study of drugs, particularly drug handling and drug response) and…
Chapter 46 Diabetes Mellitus David B. Sacks, M.B., Ch.B., F.R.C.Path. Diabetes mellitus is a group of metabolic disorders of carbohydrate metabolism in which glucose is underused, producing hyperglycemia. Some patients…
Chapter 56 Reproductive Endocrinology and Related Disorders T. Scott Isbell, Ph.D., Emily Jungheim, M.D. and Ann M. Gronowski, Ph.D.* Reproductive endocrinology encompasses the hormones of the hypothalamic-pituitary-gonadal axis, as well…
Chapter 18 Microfabrication and Microfluidics and Their Application to Clinical Diagnostics Lindsay A.L. Bazydlo, Ph.D. and James P. Landers, Ph.D. Background The first miniaturized analytical device with some degree of…
Chapter 40 Inherited Diseases Cindy L. Vnencak-Jones, Ph.D., F.A.C.M.G. Since the first description of the use of the polymerase chain reaction (PCR) for the diagnosis of sickle cell anemia in…
Chapter 33 The Porphyrias and Other Disorders of Porphyrin Metabolism Michael N. Badminton, M.B., Ch.B, Ph.D., F.R.C.Path., Sharon D. Whatley, Ph.D., Allan C. Deacon, Ph.D., F.R.C.Path. and George H. Elder,…
Chapter 12 Electrophoresis Raymond E. Karcher, Ph.D. and James P. Landers, Ph.D.* Developments in deoxyribonucleic acid (DNA) testing, improvements in ease of performance through automation, and advantages of speed and…
