Pharmacokinetics
Figure 2–1 The absorption, distribution, biotransformation (metabolism), and excretion of a typical drug after its oral administration. DRUG ABSORPTION Drug absorption refers to the passage of drug molecules from the…
Drugs for Pain, Inflammation, and Arthritic Disorders
Figure 30–1 Pathogenesis of rheumatoid arthritis and sites of action of selected antirheumatic drugs. In this simplified view of the immune system, antigen-presenting cells phagocytose antigens and present them to…
Antiarrhythmic Drugs
Figure 14–1 Relationships between ion currents, cardiac action potentials, and the findings on surface ECG. The normal heartbeat originates in the SA node. The impulse is conducted through internodal fibers…
Drugs Affecting Fertility and Reproduction
Figure 34–1 Biosynthesis of sex steroids. In the ovary, pregnenolone is converted to androstenedione and testosterone in thecal cells. These steroids are then converted to estrone and estradiol in granulosa…
Local and General Anesthetics
Figure 21–1 Structures of selected local anesthetics. Local anesthetics are formulated as hydrochloride salts with a pH less than 7, as the ionized molecule is more soluble and stable than…
Autacoid Drugs
Autacoids regulate certain aspects of gastrointestinal, uterine, and renal function, and they are involved in pain, fever, inflammation, allergic reactions, asthma, thromboembolic disorders, and other pathologic conditions. Drugs that inhibit…
Drugs for Diabetes Mellitus
Differences in the amino acid composition of insulins are shown in the following table. Secretion Insulin secretion has meal-stimulated and basal components. Insulin release is activated by the rise in…
Antineoplastic and Immunomodulating Drugs
Figure 45–1 Cell cycle activity of antineoplastic drugs. The cycle of cell replication includes the sequential phases of G1 (gap 1), S (DNA synthesis), G2 (gap 2), and M (mitosis)….
Inhibitors of Bacterial Cell Wall Synthesis
Figure 38–1 Comparison of the cell envelopes of gram-positive and gram-negative bacteria. (A) The gram-positive bacterium has a thick cell wall but does not have an outer membrane. β-Lactamases are…
Antiviral Drugs
Figure 43–1 Mechanisms of action of nucleoside analogues used in the treatment of viral infections. Acyclovir and other nucleoside analogues are converted to active nucleoside triphosphates by viral and host…
