The other commonly used term for adenosis is atypical adenomatous hyperplasia (AAH). We prefer the term adenosis, as prefacing adenomatous hyperplasia with atypical has adverse consequences both in terms of…
Evaluating an atypical focus in a needle biopsy of the prostate should be a methodical process. When reviewing needle biopsies, one should develop a mental balance sheet where on one…
Low-grade PIN consists of preexisting benign prostate glands with minimal epithelial proliferation in terms of nuclear stratification, where nuclei are minimally enlarged without prominent nucleoli (Figs. 5.3 and 5.4, eFigs….
THE 2005 INTERNATIONAL SOCIETY OF UROLOGICAL PATHOLOGY MODIFICATIONS TO THE GLEASON GRADE Why the Need for a Consensus on Gleason Grading? Since the late 1960s when the Gleason grading system…
In the presence of inflammation, one must be cautious in diagnosing cancer (Figs. 10.16 and 10.17). Rarely, one can establish a diagnosis of cancer associated with inflammation (Fig. 10.18). Figure…
Approximately half of all reported cases of STUMP demonstrate the first pattern of hypercellular stroma containing atypical cells intermixed with, but not compressing, benign glands. The atypical stromal cells in…
Amyloid Vascular amyloid can be identified in 2% to 10% of prostates removed for hyperplasia or carcinoma.19–22 Patients with multiple myeloma, primary amyloidosis of the kidney, or chronic debilitating diseases…
USUAL PROSTATE ADENOCARCINOMA WITH NEUROENDOCRINE DIFFERENTIATION In the early 1970s, Azzopardi and Evans4 recognized the presence of argentaffin cells within normal prostatic adenocarcinoma. Immunohistochemically, usual adenocarcinoma of the prostate demonstrates…
MISCELLANEOUS URETHRAL POLYPS A rare type of urethral polyp arising in the prostatic urethra is fibroepithelial polyp (Figs. 18.3 and 18.4, eFigs. 18.2 to 18.7).10 They are found at all…
The cribriform pattern of prostatic duct adenocarcinomas is more commonly seen deeper within the tissue, although it may also be noted in the exophytic urethral component of the lesion (Figs….
