http://evolve.elsevier.com/Edmunds/NP/ Increased Focus on Primary Care Primary care as a concept involves the provision of integrated, accessible health care services by clinicians who are accountable for addressing “personal health care…
Figure 2–1 The absorption, distribution, biotransformation (metabolism), and excretion of a typical drug after its oral administration. DRUG ABSORPTION Drug absorption refers to the passage of drug molecules from the…
Figure 30–1 Pathogenesis of rheumatoid arthritis and sites of action of selected antirheumatic drugs. In this simplified view of the immune system, antigen-presenting cells phagocytose antigens and present them to…
Figure 14–1 Relationships between ion currents, cardiac action potentials, and the findings on surface ECG. The normal heartbeat originates in the SA node. The impulse is conducted through internodal fibers…
Figure 34–1 Biosynthesis of sex steroids. In the ovary, pregnenolone is converted to androstenedione and testosterone in thecal cells. These steroids are then converted to estrone and estradiol in granulosa…
Figure 21–1 Structures of selected local anesthetics. Local anesthetics are formulated as hydrochloride salts with a pH less than 7, as the ionized molecule is more soluble and stable than…
Autacoids regulate certain aspects of gastrointestinal, uterine, and renal function, and they are involved in pain, fever, inflammation, allergic reactions, asthma, thromboembolic disorders, and other pathologic conditions. Drugs that inhibit…
Differences in the amino acid composition of insulins are shown in the following table. Secretion Insulin secretion has meal-stimulated and basal components. Insulin release is activated by the rise in…
Figure 45–1 Cell cycle activity of antineoplastic drugs. The cycle of cell replication includes the sequential phases of G1 (gap 1), S (DNA synthesis), G2 (gap 2), and M (mitosis)….
Figure 38–1 Comparison of the cell envelopes of gram-positive and gram-negative bacteria. (A) The gram-positive bacterium has a thick cell wall but does not have an outer membrane. β-Lactamases are…
