Diagnosis of Limited Adenocarcinoma of the Prostate
Evaluating an atypical focus in a needle biopsy of the prostate should be a methodical process. When reviewing needle biopsies, one should develop a mental balance sheet where on one…
PATHOLOGY & LABORATORY MEDICINE
Preneoplastic Lesions in the Prostate: Prostatic Intraepithelial Neoplasia and Intraductal Carcinoma of the Prostate
Low-grade PIN consists of preexisting benign prostate glands with minimal epithelial proliferation in terms of nuclear stratification, where nuclei are minimally enlarged without prominent nucleoli (Figs. 5.3 and 5.4, eFigs….
Grading of Prostatic Adenocarcinomas
THE 2005 INTERNATIONAL SOCIETY OF UROLOGICAL PATHOLOGY MODIFICATIONS TO THE GLEASON GRADE Why the Need for a Consensus on Gleason Grading? Since the late 1960s when the Gleason grading system…
Findings of Atypical Glands Suspicious for Cancer
In the presence of inflammation, one must be cautious in diagnosing cancer (Figs. 10.16 and 10.17). Rarely, one can establish a diagnosis of cancer associated with inflammation (Fig. 10.18). Figure…
Mesenchymal Tumors and Tumor-like Conditions
Approximately half of all reported cases of STUMP demonstrate the first pattern of hypercellular stroma containing atypical cells intermixed with, but not compressing, benign glands. The atypical stromal cells in…
Miscellaneous Benign and Malignant Lesions
Amyloid Vascular amyloid can be identified in 2% to 10% of prostates removed for hyperplasia or carcinoma.19–22 Patients with multiple myeloma, primary amyloidosis of the kidney, or chronic debilitating diseases…
Neuroendocrine Differentiation in the Benign and Malignant Prostate
USUAL PROSTATE ADENOCARCINOMA WITH NEUROENDOCRINE DIFFERENTIATION In the early 1970s, Azzopardi and Evans4 recognized the presence of argentaffin cells within normal prostatic adenocarcinoma. Immunohistochemically, usual adenocarcinoma of the prostate demonstrates…
Prostatic Urethral Lesions
MISCELLANEOUS URETHRAL POLYPS A rare type of urethral polyp arising in the prostatic urethra is fibroepithelial polyp (Figs. 18.3 and 18.4, eFigs. 18.2 to 18.7).10 They are found at all…
Prostatic Duct Adenocarcinoma
The cribriform pattern of prostatic duct adenocarcinomas is more commonly seen deeper within the tissue, although it may also be noted in the exophytic urethral component of the lesion (Figs….
Urothelial Carcinoma
Although for most cases, the distinction between urothelial carcinoma and poorly differentiated prostatic adenocarcinoma can be made on morphologic grounds, there is overlap in a minority of cases. Whereas usual…
