Drug–Receptor Interactions
Drug–Receptor Interactions Francis J. Alenghat and David E. Golan INTRODUCTION & CASE CONFORMATION AND CHEMISTRY OF DRUGS AND RECEPTORS Impact of Drug Binding on the Receptor Membrane Effects on Drug–Receptor…
Integrative Inflammation Pharmacology: Peptic Ulcer Disease
Integrative Inflammation Pharmacology: Peptic Ulcer Disease Dalia S. Nagel and Helen M. Shields INTRODUCTION & CASES 1 & 2 PHYSIOLOGY OF GASTRIC ACID SECRETION Neurohormonal Control of Gastric Acid Secretion…
Pharmacology of Analgesia
Pharmacology of Analgesia Robert S. Griffin and Clifford J. Woolf INTRODUCTION & CASE PHYSIOLOGY Sensory Transduction: Excitation of Primary Afferent Neurons Conduction from the Periphery to the Spinal Cord Transmission…
Pharmacology of Abnormal Electrical Neurotransmission in the Central Nervous System
INTRODUCTION With over 10 billion neurons and an estimated 1014 synaptic connections, the human brain boasts unparalleled electrical complexity. Unlike myocardial tissue, where electrical signals spread synchronously through a syncytium…
Integrative Inflammation Pharmacology: Asthma
INTRODUCTION Asthma is a chronic disease characterized by inflammation of the airways and exaggerated airway smooth muscle constriction. The symptoms of asthma include dyspnea and wheezing as well as mucus…
Histamine Pharmacology
INTRODUCTION Histamine is a biogenic amine found in many tissues, including mast cells, basophils, lymphocytes, neurons, and gastric enterochromaffin-like cells. It is an autacoid—that is, a molecule secreted locally to…
Principles of Combination Chemotherapy
Principles of Combination Chemotherapy Quentin J. Baca, Donald M. Coen, and David E. Golan INTRODUCTION & CASE ANTIMICROBIAL COMBINATION THERAPY Minimum Inhibitory Concentration and Minimum Bactericidal Concentration Types of Drug…
Pharmacology of the Hypothalamus and Pituitary Gland
Pharmacology of the Hypothalamus and Pituitary Gland Anand Vaidya and Ursula B. Kaiser INTRODUCTION & CASE HYPOTHALAMIC AND PITUITARY PHYSIOLOGY Relationship Between the Hypothalamus and Pituitary Gland Feedback Inhibition PHYSIOLOGY,…
Pharmacology of Serotonergic and Central Adrenergic Neurotransmission
INTRODUCTION This chapter introduces the neurotransmitter serotonin (5-hydroxytryptamine; 5-HT), which is a target for many drugs used to treat psychiatric disorders related to depression and anxiety. Some of these medications…
Principles of Inflammation and the Immune System
INTRODUCTION Inflammation and the immune system are closely intertwined. Inflammation is composed of a complex web of responses to tissue injury and infection, characterized by the classic signs of rubor…
