Fig. 9.1 Histological subtypes of medulloblastoma. (a) Classic histology; (b) desmoplastic histology; (c) medulloblastoma with extensive nodularity (MBEN); (d) large cell/anaplastic (LC/A) histology. Understanding the molecular biology underlying medulloblastoma is…
Fig. 16.1 Plexiform neurofibroma arising from the vagus nerve, involving the thymus gland Fig. 16.2 Plexiform neurofibroma with low cellularity and “shredded carrot” collagen Fig. 16.3 Large mediastinal soft tissue…
Fig. 15.1 Macroscopic features of a schwannoma: encapsulated mass, associated with a nerve, with homogenous yellow/tan cut surface The cut surface of schwannomas appears tan and homogenous (Fig. 15.1). There…
Fig. 4.1 Pathologic features of pilocytic astrocytoma (PA). PA is histologically characterized by the presence of neoplastic bipolar astrocytes in compact areas (a). Rosenthal fibers are a frequent feature of…
Grade I Grade II Grade III Grade IV Angiocentric glioma Diffuse astrocytoma Anaplastic astrocytoma Glioblastoma Pilocytic astrocytoma Oligodendroglioma Anaplastic oligodendroglioma Giant cell glioblastoma Subependymal giant cell astrocytoma (SEGA) Oligoastrocytoma Anaplastic…
Fig. 13.1 Gross image of AT/RT. Tumor (pink to tan mass) with areas of hemorrhage and necrosis located at the cerebellopontine angle Histopathology AT/RTs can be quite heterogeneous and are…
Fig. 12.1 Histologic features of normal choroid plexus and choroid plexus tumors. (a) Normal choroid plexus demonstrating typical “cobblestone” appearance (40×). (b) Choroid plexus papilloma, in contrast to normal choroid…
Definite—One primary, two secondary, or one secondary plus two tertiary features Probable—One secondary, plus one tertiary or three tertiary features Suspect—One secondary, or two tertiary features Primary features Facial angiofibromasa…
Fig. 1.1 Genes involved in predisposition to brain tumors. Cancer predisposing syndromes can be grouped in a variety of ways. Some syndromes will have many clinical manifestations, among which cancer…
Fig. 3.1 Examples of FISH applications in molecular neuropathology: (a–c) 1p evaluation, 1p red, 1q green: (a) Maintenance of 1p (2:2 signals), (b) 1p loss (1:2 signals), (c) relative deletions/superloss…
