Chapter 2 Population Model Concepts and Terminology 2.1 Introduction Pharmacometrics is a science that employs mathematical models in diverse applications of the pharmaceutical sciences. These models are used to concisely…
Chapter 9User-Written Models 9.1 Introduction Nonlinear mixed effect models are useful for the construction of an immense variety of pharmacometric models. The PRED and PREDPP routines of NONMEM provide flexibility…
Chapter 6 Interpreting the NONMEM Output 6.1 Introduction The appropriate interpretation of the output from NONMEM may well be considered the art in what is often referred to as the…
Chapter 10PK/PD Models 10.1 Introduction Most of the discussion up to this point in our text has been in regard to pharmacokinetics (PK) alone. However, PK considerations in the development…
Chapter 1The Practice of Pharmacometrics 1.1 Introduction In the course of the development and clinical use of pharmaceutical products, many questions arise that require quantitative answers regarding issues of safety…
