Basicmedical Key

Stage Description pTX Primary tumor cannot be assessed pT0 No evidence of primary tumor pTis Melanoma in situ pT1a Melanoma 1.0 mm or less in thickness, no ulceration, <1 mitoses/mm2…

Fig. 10.1 Blue nevus. (a) Pigmented fusiform and dendritic cells between thickened collagen fibers (×10). (b) Note the delicate branched dendritic processes (×40) Cellular Blue Nevus The cellular variant of…

Fig. 12.1 Age distribution for 302 patients with neurothekeoma (compiled from [9, 14]) Fig. 12.2 Neurothekeoma, shown here as a well-defined, red-pink nodule. The unusually prominent, arborizing vasculature seen beneath…

Clinical and dermoscopic findings Acral nevus Acral lentiginous melanoma Onset Childhood and adolescence Middle-aged adult and elderly Symmetry (A) Symmetry Asymmetry Border (B) Sharp, irregular Irregular Color (C) Homogeneous or…

Fig. 13.1 The variable histological appearances of MIS. (a) Intraepidermal pagetoid scatter of cytologically atypical melanocytes containing abundant melanin (×10). (b) Intraepidermal pagetoid scatter of cytologically atypical, but less pigmented…

Fig. 17.1 Metastatic melanoma involving the subcapsular sinus Fig. 17.2 Metastatic melanoma involving the lymph node parenchyma Immunohistochemistry may be very helpful when examining SLN. As with melanomas at other…

Common acquired nevi Dysplastic nevi Melanoma Well nested at peripheral junctional component (circumscribed) Mild–moderate: circumscribed Single-cell, non-nested melanocytes predominate Moderate–severe: poorly circumscribed Maturation (senescence) transition from pigmented nested melanocytes in…

Women 20–40 years old Back > face, extremities History of biopsy or excision, with or without free margins Appear within weeks–months after excision Pigment usually within margins of scar Pigment fades with…

Fig. 15.1 Nodular malignant melanoma with an adjacent associated nevus Another criterion favoring the interpretation of a primary rather than metastatic melanoma is the presence of regressive features, including an…

Fig. 3.1 Compound congenital melanocytic nevus: in addition to nests, there is a proliferation of single cells dispersed along the epidermal basal layer, which lack significant cytologic atypia (a). Malignant…