INTRODUCTION In 1928, Alexander Fleming made a chance discovery that would revolutionize the treatment of bacterial infections. He observed that certain molds produce a compound that inhibits the growth of…
INTRODUCTION While infectious diseases and cancers have different underlying etiologies, from a pharmacologic perspective, the broad principles of treatment are similar. One common thread in these pharmacologic strategies is the…
Integrative Inflammation Pharmacology: Peptic Ulcer Disease Dalia S. Nagel and Helen M. Shields INTRODUCTION & CASES 1 & 2 PHYSIOLOGY OF GASTRIC ACID SECRETION Neurohormonal Control of Gastric Acid Secretion…
Drug–Receptor Interactions Francis J. Alenghat and David E. Golan INTRODUCTION & CASE CONFORMATION AND CHEMISTRY OF DRUGS AND RECEPTORS Impact of Drug Binding on the Receptor Membrane Effects on Drug–Receptor…
Pharmacology of Analgesia Robert S. Griffin and Clifford J. Woolf INTRODUCTION & CASE PHYSIOLOGY Sensory Transduction: Excitation of Primary Afferent Neurons Conduction from the Periphery to the Spinal Cord Transmission…
INTRODUCTION With over 10 billion neurons and an estimated 1014 synaptic connections, the human brain boasts unparalleled electrical complexity. Unlike myocardial tissue, where electrical signals spread synchronously through a syncytium…
INTRODUCTION Asthma is a chronic disease characterized by inflammation of the airways and exaggerated airway smooth muscle constriction. The symptoms of asthma include dyspnea and wheezing as well as mucus…
INTRODUCTION Histamine is a biogenic amine found in many tissues, including mast cells, basophils, lymphocytes, neurons, and gastric enterochromaffin-like cells. It is an autacoid—that is, a molecule secreted locally to…
Principles of Combination Chemotherapy Quentin J. Baca, Donald M. Coen, and David E. Golan INTRODUCTION & CASE ANTIMICROBIAL COMBINATION THERAPY Minimum Inhibitory Concentration and Minimum Bactericidal Concentration Types of Drug…
Pharmacology of the Hypothalamus and Pituitary Gland Anand Vaidya and Ursula B. Kaiser INTRODUCTION & CASE HYPOTHALAMIC AND PITUITARY PHYSIOLOGY Relationship Between the Hypothalamus and Pituitary Gland Feedback Inhibition PHYSIOLOGY,…
