INTRODUCTION Cholinergic pharmacology is centered on the properties of the first identified neurotransmitter, acetylcholine (ACh). The functions of cholinergic pathways are diverse; generally, they involve the neuromuscular junction (NMJ), the…
Pharmacology of Cholesterol and Lipoprotein Metabolism Tibor I. Krisko, Ehrin J. Armstrong, and David E. Cohen INTRODUCTION & CASE BIOCHEMISTRY AND PHYSIOLOGY OF CHOLESTEROL AND LIPOPROTEIN METABOLISM Metabolism of ApoB-Containing…
Pharmacology of Bacterial Infections: DNA Replication, Transcription, and Translation Alexander J. McAdam and Donald M. Coen INTRODUCTION & CASE BIOCHEMISTRY OF BACTERIAL DNA REPLICATION, TRANSCRIPTION, AND TRANSLATION DNA Structure DNA…
INTRODUCTION While the heart provides cardiac output, the blood vessels play a critical role in the distribution of oxygen and nutrients to metabolically active tissues. Blood flow to these tissues…
Pharmacology of GABAergic and Glutamatergic Neurotransmission Stuart A. Forman, Hua-Jun Feng, Janet Chou, Jianren Mao, and Eng H. Lo INTRODUCTION & CASE OVERVIEW OF GABAERGIC AND GLUTAMATERGIC NEUROTRANSMISSION PHYSIOLOGY OF…
Pharmacology of Cardiac Contractility Ehrin J. Armstrong INTRODUCTION & CASE PHYSIOLOGY OF CARDIAC CONTRACTION Myocyte Anatomy Myocyte Contraction Regulation of Contractility The Sodium Pump and Sodium–Calcium Exchange Calcium Storage and…
Pharmacology of Dopaminergic Neurotransmission David G. Standaert and Victor W. Sung INTRODUCTION & CASE BIOCHEMISTRY AND CELL BIOLOGY OF DOPAMINERGIC NEUROTRANSMISSION Dopamine Storage, Release, Reuptake, and Inactivation Dopamine Receptors Central…
Pharmacology of the Adrenal Cortex Rajesh Garg and Gail K. Adler INTRODUCTION & CASE OVERVIEW OF THE ADRENAL CORTEX GLUCOCORTICOIDS Physiology Synthesis Metabolism Physiologic Actions Regulation Pathophysiology Adrenal Insufficiency Glucocorticoid…
INTRODUCTION This chapter reviews the physiology and pharmacology of insulin, glucagon, and the other major hormones that regulate glucose homeostasis. Diabetes mellitus is clinically the most common disease of these…
2 Pharmacodynamics Quentin J. Baca and David E. Golan INTRODUCTION & CASE DRUG–RECEPTOR BINDING DOSE–RESPONSE RELATIONSHIPS Graded Dose–Response Relationships Quantal Dose–Response Relationships DRUG–RECEPTOR INTERACTIONS Agonists Antagonists Competitive Receptor Antagonists Noncompetitive…
