Amyloid Vascular amyloid can be identified in 2% to 10% of prostates removed for hyperplasia or carcinoma.19–22 Patients with multiple myeloma, primary amyloidosis of the kidney, or chronic debilitating diseases…
USUAL PROSTATE ADENOCARCINOMA WITH NEUROENDOCRINE DIFFERENTIATION In the early 1970s, Azzopardi and Evans4 recognized the presence of argentaffin cells within normal prostatic adenocarcinoma. Immunohistochemically, usual adenocarcinoma of the prostate demonstrates…
MISCELLANEOUS URETHRAL POLYPS A rare type of urethral polyp arising in the prostatic urethra is fibroepithelial polyp (Figs. 18.3 and 18.4, eFigs. 18.2 to 18.7).10 They are found at all…
The cribriform pattern of prostatic duct adenocarcinomas is more commonly seen deeper within the tissue, although it may also be noted in the exophytic urethral component of the lesion (Figs….
Although for most cases, the distinction between urothelial carcinoma and poorly differentiated prostatic adenocarcinoma can be made on morphologic grounds, there is overlap in a minority of cases. Whereas usual…
Therapy with LHRH agonists and flutamide may result in three different histologic patterns in prostate cancer. The neoplastic acini may become atrophic (Fig. 14.2, eFigs. 14.6 to 14.12).4,7–13 At higher…
Clinical prostatitis may give rise to elevated serum prostate-specific antigen (PSA) elevations.8 There are conflicting studies as to whether histologic evidence of either acute or chronic inflammation on biopsy correlates…
Epigenetic Changes in Prostate Cancer Changes in DNA methylation marks, accompanied by epigenetic gene silencing, appear to be the earliest somatic genome changes in prostate cancer.21 New generation of assay…
The anterior fibromuscular stroma, which occupies approximately one-third of the prostate, contains very few glands and consists of smooth muscle tissue and dense fibrous tissue. The central zone forms a…
Currently, there is no consensus as to the optimal method for measuring tumor length or percentage of cancer on a core when there are two or more foci of prostate…
