Pharmacology of Hemostasis and Thrombosis
INTRODUCTION Blood carries oxygen and nutrients to tissues and takes metabolic waste products away from tissues. Humans have developed a well-regulated system of hemostasis to keep the blood fluid and…
Pharmacology of Eicosanoids
Pharmacology of Eicosanoids David M. Dudzinski and Charles N. Serhan INTRODUCTION & CASE PHYSIOLOGY OF EICOSANOID METABOLISM Generation of Arachidonic Acid and Omega-3 Fatty Acids Cyclooxygenase Pathway Prostaglandins Thromboxane and…
Integrative Cardiovascular Pharmacology: Hypertension, Ischemic Heart Disease, and Heart Failure
INTRODUCTION In Chapters 20–25, cardiovascular pharmacology is considered in the context of individual physiologic systems. For example, diuretics are discussed in the context of volume regulation, while inhibitors of angiotensin…
Pharmacology of Viral Infections
Pharmacology of Viral Infections Jonathan Z. Li and Donald M. Coen INTRODUCTION & CASE PHYSIOLOGY OF VIRAL REPLICATION Viral Life Cycle PHARMACOLOGIC CLASSES AND AGENTS Inhibition of Viral Attachment and…
Pharmacology of Cardiac Rhythm
INTRODUCTION The human heart is both a mechanical and an electrical organ. To perfuse the body adequately with blood, the mechanical and electrical components of the heart must work in…
Drug Discovery and Preclinical Development
INTRODUCTION Over the past decade, the US Food and Drug Administration (FDA) has approved approximately 260 new therapeutics, including 220 new molecular entities (small molecules) and 42 biotherapeutics (generally, recombinant…
Pharmacology of Drugs of Abuse
Pharmacology of Drugs of Abuse Peter R. Martin and Sachin Patel INTRODUCTION & CASE DEFINITIONS MECHANISMS OF TOLERANCE, DEPENDENCE, AND WITHDRAWAL Tolerance Dependence and Withdrawal MECHANISMS OF SUBSTANCE USE DISORDERS…
Pharmacology of Volume Regulation
Pharmacology of Volume Regulation Hakan R. Toka and Seth L. Alper INTRODUCTION & CASE PHYSIOLOGY OF VOLUME REGULATION Determinants of Intravascular Volume Volume Sensors Volume Regulators Renin-Angiotensin-Aldosterone System Natriuretic Peptides…
Pharmacology of Reproduction
INTRODUCTION This chapter presents endocrine pharmacology relevant to both the male and female reproductive tracts. Although men and women differ in their hormonal profiles, androgens and estrogens are both under…
