Chapter 58 Newborn Screening and Inborn Errors of Metabolism Marzia Pasquali, Ph.D., F.A.C.M.G. and Nicola Longo, M.D., Ph.D.* An inborn error of metabolism (IEM) is a genetically determined biochemical disorder…
Chapter 17 Nucleic Acid Techniques Carl T. Wittwer, M.D., Ph.D. and Noriko Kusukawa, Ph.D. Molecular diagnostics requires techniques to detect extremely low concentrations of nucleic acids in a background of…
Chapter 54 The Adrenal Cortex Roger L. Bertholf, Ph.D., Ishwarlal Jialal, M.D., Ph.D., F.R.C.Path(London), D.A.B.C.C. and William E. Winter, M.D.* The adrenal cortex and gonads produce steroid hormones. Steroids are…
Chapter 35 Clinical Toxicology Loralie Langman, Ph.D., F.C.A.C.B., D.A.B.C.C.(C.C.,M.B., T.C.), D.A.B.F.T., Laura Bechtel, Ph.D., D.A.B.C.C. and Christopher P. Holstege, M.D. Toxicology is a broad, multidisciplinary science whose goal is to…
Chapter 59 Hemostasis Russell A. Higgins, M.D., Steve Kitchen, Ph.D. and John D. Olson, M.D., Ph.D. Hemostasis is the mechanism by which animals with a vascular system protect themselves from…
Chapter 8 Quality Management George G. Klee, M.D., Ph.D. and James O. Westgard, Ph.D. The principles of quality management, assurance, and control have become the foundation by which clinical laboratories…
Chapter 32 Hemoglobin, Iron, and Bilirubin Trefor Higgins, M.Sc., John H. Eckfeldt, M.D., Ph.D., James C. Barton, M.D. and Basil T. Doumas, Ph.D.* Hemoglobin (Hb), iron (Fe), and bilirubin are…
Chapter 9 Principles of Basic Techniques and Laboratory Safety Stanley F. Lo, Ph.D., D.A.B.C.C., F.A.C.B.* To reliably perform qualitative and quantitative analyses on body fluids and tissue, the clinical laboratorian…
Chapter 31 Vitamins and Trace Elements Alan Shenkin, Ph.D., and Norman B. Roberts, Ph.D., C.Chem.* Adequate supplies of vitamins and trace elements are critical in maintaining the health and development…
Chapter 22 Serum Enzymes Mauro Panteghini, M.D. and Renze Bais, Ph.D., A.R.C.P.A. Measurements of enzymes are used in medicine in two major ways. Enzymes are measured in serum and other…
