Lung Transplant Pathology
Acute rejection grade A0 No rejection A1 Minimal rejection A2 Mild rejection A3 Moderate rejection A4 Severe rejection Airway inflammation grade B0 No significant inflammation B1R Low-grade inflammation B2R High-grade…
Heart Transplant Pathology
Fig. 2.1 Contraction-band artifact. Longitudinal (a) and cross-sectional (b) views of myocytes with contraction-band artifact. The contraction bands cause more and less eosinophilic regions that can mimic myocytolysis and/or coagulation…
Kidney Transplant Pathology
Fig. 4.1 Renal tissue core obtained with a 16-gauge needle contains several blood-filled glomeruli, which appear as congested bulging hemispheres (arrows). Sclerotic and inflamed glomeruli with little or no circulating…
Post-transplantation Lymphoproliferative Disorders
Early Lesions Plasmacytic hyperplasia Infectious mononucleosis-like Polymorphic PTLDs B-Cell Neoplasms : Diffuse large B-cell lymphoma Burkitt lymphoma Plasma cell myeloma Plasmacytoma-like lesions T-Cell Neoplasms: Peripheral T-cell lymphoma, NOS Hepatosplenic T-cell…
Liver Transplant Pathology
Fig. 5.1 Large droplet macrovesicular steatosis is shown as fat droplets occupying greater than half of the cytoplasm and displacing the nucleus Fig. 5.2 Small droplet macrovesicular steatosis is shown…
Pancreas Transplant Pathology
Category Histology Comments Normal Absent or inactive septal inflammation Active inflammation includes blastic lymphocytes and/or eosinophils Indeterminate for ACR Active septal inflammation without additional findings No ductitis or venulitis Grade…
Histocompatibility and Immunogenetics for Solid Organ Transplantation
Fig. 1.1 Genetic map of the human and mouse MHCs. (a) Schematic map of human MHC on chromosome 6. Illustrations are not drawn to scale. The centromere (circle) and major…
Small Bowel Transplant Pathology
Grade of ACR Apoptotic bodies per 10 consecutive crypts (n) Epithelial injury Lamina propria inflammation No ACR ≤2 None Normal components Indeterminate 3–5 Minimal, usually focal Minimal, usually localized Mild…
Vascularized Composite Tissue Transplant Pathology
Fig. 7.1 (a–d) Examples of Grade 0—no rejection. Note the normal epidermis and minimal, superficial perivascular, lymphocyte-predominant inflammatory infiltrate 7.1.2 Grade I Rejection: Mild The presence of mild inflammation characterizes…
