Hyaline Vascular Castleman Disease Pei Lin, MD Key Facts Clinical Issues Young adults Lymphadenopathy, localized Excision is usually curative Microscopic Pathology Large follicles with regressed (involuted) germinal centers 2 or…
Progressive Transformation of Germinal Centers Pei Lin, MD Key Facts Terminology Progressive transformation of germinal centers (PTGC) Clinical Issues Young adults most commonly affected Asymptomatic localized lymphadenopathy in most patients…
Cryptorchidism Steven S. Shen, MD, PhD Key Facts Terminology Testis present outside scrotum and cannot be moved into scrotum Clinical Issues Most common birth defect of male genitalia 1% of…
Vasculitis, ANCA-Related Monica P. Revelo, MD, PhD Key Facts Terminology Systemic vasculitis involving small to medium-sized vessels associated with or caused by ANCA Kidney involvement is characterized by prominent crescents…
Alport Syndrome Helen Liapis, MD Key Facts Etiology/Pathogenesis 85% X-linked inheritance of mutations in COL4A5 15% autosomal recessive COL4A3, COL4A4 Clinical Issues Presentation Hematuria, proteinuria, sensorineural deafness, hypertension, eye abnormalities…
Lupus Nephritis Shane M. Meehan, MBBCh Key Facts Terminology Systemic autoimmune disease manifested by inflammation of skin, joints, kidneys, and central nervous system IgG autoantibodies to DNA, RNA, proteins, phospholipids…
Molecular Factors Index Molecular Factors Discussed Gene Gene Location Official Gene Symbol and Name Chapter Term Found ABCA3 16p13.3 ABCA3; ATP-binding cassette, sub-family A (ABC1), member 3 Congenital Surfactant Deficiency…
Testicular Torsion Jessica M. Comstock, MD Key Facts Etiology/Pathogenesis Intravaginal torsion (torsion of testis within tunica vaginalis) Predisposed by bell-clapper deformity, puberty, and cryptorchidism Extravaginal torsion (torsion of testis, tunica…
Testicular Regression Syndrome Larissa V. Furtado, MD Key Facts Terminology Vanishing testes syndrome Etiology/Pathogenesis Result from atrophy and disappearance in fetal life of an initially normal testis Clinical Issues Affects…
Vaginal Adenosis Marisa R. Nucci, MD Key Facts Terminology Müllerian-type epithelium replacing squamous mucosa or forming glands in lamina propria Etiology/Pathogenesis Prenatal exposure to diethylstilbestrol (DES) in utero Clinical Issues…
