Infectious Mononucleosis Syndromes
Infectious Mononucleosis Syndromes Carla S. Wilson, MD, PhD Key Facts Terminology IM is an acute illness Mainly due to EBV infection ˜ 20% of cases due to CMV or other…
Acute Thymic Involution
Acute Thymic Involution Jessica M. Comstock, MD Key Facts Terminology Incidental thymic involution caused by endogenous steroid release in response to various stressful situations Etiology/Pathogenesis Numerous stressors including infection, chronic…
Transient Erythroblastopenia of Childhood
Transient Erythroblastopenia of Childhood Kathryn Foucar, MD Key Facts Terminology Self-limited red cell aplasia characterized by Normocytic/normochromic anemia with reticulocytopenia Decreased erythroid lineage in bone marrow (red cell aplasia) Etiology/Pathogenesis…
Hemophagocytic Lymphohistiocytosis
Hemophagocytic Lymphohistiocytosis Sa A. Wang, MD Key Facts Terminology Cytokine dysfunction, resulting in activation of T lymphocytes and macrophages Leads to systemic symptoms and organ damage Etiology/Pathogenesis Inherited genetic or…
Mycobacterial Infection
Mycobacterial Infection Tariq Muzzafar, MBBS Key Facts Clinical Issues High index of suspicion essential for diagnosis Definitive diagnosis by histology and culture of LN Molecular methods enable quicker identification of…
Toxoplasma Lymphadenitis
Toxoplasma Lymphadenitis Carlos E. Bueso-Ramos, MD, PhD Key Facts Etiology/Pathogenesis Toxoplasma gondii is parasitic protozoan Cat is definitive host for sexual stage of reproduction Trophozoite-containing oocysts are eliminated in feces…
Chronic Granulomatous Lymphadenitis
Chronic Granulomatous Lymphadenitis C. Cameron Yin, MD, PhD Key Facts Terminology Granulomatous inflammation is specific type of inflammatory response Characterized by accumulation of modified macrophages (epithelioid cells) Initiated by infectious…
Rosai-Dorfman Disease
Rosai-Dorfman Disease L. Jeffrey Medeiros, MD Roberto N. Miranda, MD Key Facts Terminology Rosai-Dorfman disease (RDD) and sinus histiocytosis with massive lymphadenopathy are equivalent terms Etiology/Pathogenesis Unknown; histologic features are…
Kimura Disease
Kimura Disease C. Cameron Yin, MD, PhD Key Facts Terminology Chronic inflammatory disease that affects subcutaneous tissue and regional lymph nodes Etiology/Pathogenesis Unknown; infectious cause suspected Clinical Issues Mainly in…
Infectious Mononucleosis Lymphadenitis
Infectious Mononucleosis Lymphadenitis Pei Lin, MD Key Facts Etiology/Pathogenesis Epstein-Barr virus infection Clinical Issues Fever Pharyngitis Lymphadenopathy Microscopic Pathology Follicular and interfollicular hyperplasia Range of cells from small mature forms…
