Infectious Mononucleosis Lymphadenitis



Infectious Mononucleosis Lymphadenitis


Pei Lin, MD









This image shows Epstein-Barr virus infection involving a tonsil. Marked lymphoid hyperplasia with many tingible body macrophages, with focal karyorrhexis and exudate image, are shown.






Small to large lymphoid cells, eosinophils, and plasma cells are seen in this image of EBV lymphadenitis. The large cells image are immunoblasts with prominent nucleoli.


TERMINOLOGY



Synonyms



  • Epstein-Barr virus (EBV) lymphadenitis, Pfeiffer disease, glandular fever



ETIOLOGY/PATHOGENESIS


Infectious Agents



  • Epstein-Barr virus


CLINICAL ISSUES


Epidemiology



  • Age



    • Mostly adolescents and young adults in USA



    • Even younger age in developing countries


  • Gender



    • No gender preference


Presentation



  • Fever


  • Pharyngitis


  • Lymphadenopathy


  • Peripheral blood lymphocytosis of atypical lymphocytes


Laboratory Tests



  • Monospot test (a.k.a. heterophile antibody test)


  • EBV-specific antibody tests by immunofluorescence



    • Elevated IgM antiviral capsid antigen (VCA) and absence of antibodies to EBV nuclear antigen (anti-EBNA) indicate acute infection



Prognosis



  • Usually self-limited; EBV rarely fatal, mostly in patients with immunodeficiency



    • EBV can also cause hemophagocytic syndrome or chronic active EBV infection


MICROSCOPIC PATHOLOGY


Histologic Features

Jul 8, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Infectious Mononucleosis Lymphadenitis
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