Nodal Follicular Lymphoma C. Cameron Yin, MD, PhD Key Facts Terminology B-cell neoplasm composed of germinal center B cells (centrocytes and centroblasts) Etiology/Pathogenesis Overexpression of antiapoptotic Bcl-2 due to t(14;18)…
Splenic Diffuse Red Pulp Small B-cell Lymphoma Roberto N. Miranda, MD Key Facts Terminology Abbreviation: SDRP SBCL Provisional entity in 2008 WHO classification Clinical Issues Low level of lymphocytosis Splenomegaly;…
Inflammatory Pseudotumor-like Follicular Dendritic Cell Tumor Roberto N. Miranda, MD Key Facts Terminology Inflammatory pseudotumor-like follicular dendritic cell tumor (IPT-FDCT) Considered variant of follicular dendritic cell sarcoma Classification is controversial…
Post-Chemotherapy Histiocyte-rich Pseudotumor of Spleen Roberto N. Miranda, MD Key Facts Terminology Residual splenic mass after chemotherapy composed of viable nonneoplastic cells and necrotic neoplastic cells Etiology/Pathogenesis Chemotherapy is toxic…
Lymphomatoid Granulomatosis Francisco Vega, MD, PhD Key Facts Terminology Extranodal angiocentric &/or angiodestructive EBV(+) B-cell lymphoproliferative disorder Clinical Issues Most frequent in young adults (˜ 30-40 years) Lung is most…
Mycosis Fungoides Sa A. Wang, MD Key Facts Terminology Primary cutaneous T-cell lymphoma characterized by Epidermotropism Clinical course showing stepwise evolution of patches, plaques, and tumors Clinical Issues Overall indolent…
Autoimmune Lymphoproliferative Syndrome Sa A. Wang, MD Key Facts Etiology/Pathogenesis Disease of disrupted lymphocyte homeostasis as result of defective Fas-mediated apoptosis Many mutations have been identified in ALPS Type I:…
Classical Hodgkin Lymphoma Francisco Vega, MD, PhD Key Facts Clinical Issues CHL can involve extranodal tissues Most common: Spleen, lungs, liver, and bone marrow Macroscopic Features Variable patterns of splenic…
Adult T-cell Leukemia/Lymphoma, HTLV-1+ Carlos E. Bueso-Ramos, MD, PhD Roberto N. Miranda, MD Key Facts Terminology Peripheral T-cell leukemia/lymphoma caused by human T-cell lymphotropic virus type 1 (HTLV-1) 4 clinical…
Nodular Lymphocyte Predominant Hodgkin Lymphoma Pei Lin, MD Key Facts Clinical Issues Peak incidence in 4th decade, affects all age groups Patients often present with stage I or II nodal…
