Mast Cell Disease

Jul 8, 2016 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Mast Cell Disease

Mast Cell Disease Carlos E. Bueso-Ramos, MD, PhD Roberto N. Miranda, MD L. Jeffrey Medeiros, MD Key Facts Clinical Issues Multiple clinical variants; common variants are Cutaneous mastocytosis Indolent systemic…

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Follicular Lymphoma

Jul 8, 2016 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Follicular Lymphoma

Follicular Lymphoma Roberto N. Miranda, MD Key Facts Terminology Follicular lymphoma (FL) Etiology/Pathogenesis Bcl-2 overexpression is present in most cases of FL Results from t(14;18)(q32;q21)/IgH–BCL2 Other factors are involved in…

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Histiocytic Sarcoma

Jul 8, 2016 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Histiocytic Sarcoma

Histiocytic Sarcoma Roberto N. Miranda, MD Key Facts Terminology Malignant neoplasm composed of mature histiocytes Diagnosis based mainly on morphology and immunophenotype Etiology/Pathogenesis Transdifferentiation in subset of cases B-cell lymphoma…

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Mantle Cell Lymphoma

Jul 8, 2016 by in PATHOLOGY & LABORATORY MEDICINE Comments Off on Mantle Cell Lymphoma

Mantle Cell Lymphoma Roberto N. Miranda, MD Key Facts Etiology/Pathogenesis CCND1-IGH/t(11;14)(q13;q32) resulting in Cyclin-D1 overexpression in most cases Clinical Issues MCL is nodal-based disease but extranodal sites of involvement are…

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