Mast Cell Disease
Mast Cell Disease Carlos E. Bueso-Ramos, MD, PhD Roberto N. Miranda, MD L. Jeffrey Medeiros, MD Key Facts Clinical Issues Multiple clinical variants; common variants are Cutaneous mastocytosis Indolent systemic…
Follicular Lymphoma
Follicular Lymphoma Roberto N. Miranda, MD Key Facts Terminology Follicular lymphoma (FL) Etiology/Pathogenesis Bcl-2 overexpression is present in most cases of FL Results from t(14;18)(q32;q21)/IgH–BCL2 Other factors are involved in…
Histiocytic Sarcoma
Histiocytic Sarcoma Roberto N. Miranda, MD Key Facts Terminology Malignant neoplasm composed of mature histiocytes Diagnosis based mainly on morphology and immunophenotype Etiology/Pathogenesis Transdifferentiation in subset of cases B-cell lymphoma…
Hairy Cell Leukemia Variant
Hairy Cell Leukemia Variant Roberto N. Miranda, MD Key Facts Terminology Hairy cell leukemia variant (HCL-v) Mature B-cell neoplasm involving peripheral blood, bone marrow, and spleen Resembles classical HCL but…
Diffuse Large B-cell Lymphoma Arising in the Spleen
Diffuse Large B-cell Lymphoma Arising in the Spleen Roberto N. Miranda, MD Key Facts Terminology Primary DLBCL of spleen is rare Involvement of splenic hilar lymph nodes and bone marrow…
Splenic Marginal Zone Lymphoma
Splenic Marginal Zone Lymphoma Roberto N. Miranda, MD Key Facts Terminology Splenic marginal zone lymphoma (SMZL), splenic B-cell marginal zone lymphoma (2008 WHO), splenic lymphoma with circulating villous lymphocytes (SLVL)…
Mantle Cell Lymphoma
Mantle Cell Lymphoma Roberto N. Miranda, MD Key Facts Etiology/Pathogenesis CCND1-IGH/t(11;14)(q13;q32) resulting in Cyclin-D1 overexpression in most cases Clinical Issues MCL is nodal-based disease but extranodal sites of involvement are…
Splenic Inflammatory Pseudotumor
Splenic Inflammatory Pseudotumor Roberto N. Miranda, MD Key Facts Terminology Splenic inflammatory pseudotumor (IPT) Clinical Issues Age: 19-87 years (median: 53 years) Rare in children Slight female predominance Excision is…
Primary Cutaneous Follicle Center Lymphoma
Primary Cutaneous Follicle Center Lymphoma Roberto N. Miranda, MD Key Facts Terminology Lymphoma arising in skin composed of follicular center cells Subset of cases appear to be clinically and genetically…
Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Roberto N. Miranda, MD Key Facts Terminology CLL/SLL is neoplasm of small B lymphocytes that typically involves peripheral blood (PB), bone marrow (BM), lymph nodes,…
