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Squamous Cell Carcinoma, General Concepts Antonio L. Cubilla, MD Alcides Chaux, MD Elsa F. Velazquez, MD Distal penis includes the glans (mostly composed of corpus spongiosum and containing the penile…

Squamous Hyperplasia Antonio L. Cubilla, MD Alcides Chaux, MD Elsa F. Velazquez, MD Key Facts Terminology Thickening of mucosal squamous epithelium without atypia Most common epithelial alteration associated with penile…

Mixed Carcinoma Antonio L. Cubilla, MD Alcides Chaux, MD Elsa F. Velazquez, MD Key Facts Terminology 20% or more of at least 1 of the histological components Macroscopic Features Glans…

HPV-associated Lesions Antonio L. Cubilla, MD Alcides Chaux, MD Elsa F. Velazquez, MD Key Facts Terminology Synonyms include condyloma acuminatum and giant condyloma Exophytic and verruciform nonmalignant epithelial tumors Clear…

Mixed Germ Cell Tumors Steven S. Shen, MD, PhD Jae Y. Ro, MD, PhD Key Facts Terminology Germ cell tumor composed of > 1 histologic type of germ cell tumor,…

Squamous Cell Carcinoma, Usual Type Antonio L. Cubilla, MD Alcides Chaux, MD Elsa F. Velazquez, MD Key Facts Etiology/Pathogenesis HPV infection in about 1/4 of cases Macroscopic Features Glans frequently…

Basaloid Carcinoma Antonio L. Cubilla, MD Alcides Chaux, MD Elsa F. Velazquez, MD Key Facts Etiology/Pathogenesis HPV is detected in most cases Serotype 16 is most common Clinical Issues Represents…

Papillary Carcinoma Antonio L. Cubilla, MD Alcides Chaux, MD Elsa F. Velazquez, MD Key Facts Terminology Represents 5-15% of all penile SCC Accounts for 27-53% of all verruciform tumors Etiology/Pathogenesis…

Verrucous Carcinoma Elsa F. Velazquez, MD Antonio L. Cubilla, MD Key Facts Clinical Issues Unicentric tumors are more frequent Multicentric tumors may occur Some cases may be associated with longstanding…

Carcinoma Cuniculatum Antonio L. Cubilla, MD Alcides Chaux, MD Elsa F. Velazquez, MD Key Facts Macroscopic Features Large exoendophytic tumor with “cobblestone” appearance Affects several anatomical compartments (glans, coronal sulcus,…