Verrucous Carcinoma

Verrucous Carcinoma

Elsa F. Velazquez, MD

Antonio L. Cubilla, MD

Cut section of a partial penectomy specimen shows a verruciform tumor with sharp bulbous base confined to the lamina propria.

Graphic of a verrucous carcinoma (yellow) highlights the papillary, spiky surface and well-demarcated base. Note the VC image, corpus spongiosum image, foreskin image, albuginea image, corpus cavernosum image, and urethra image.



  • Verrucous carcinoma (VC)


  • Well-differentiated squamous cell carcinoma


  • Extremely well-differentiated verruciform squamous cell carcinoma with bulbous deep borders and lack of koilocytosis


Unknown Pathogenesis

  • Likely HPV-unrelated

  • Some cases are associated with lichen sclerosus

  • Tumor suppressor gene TP53 and its functional protein product p53 are believed to be involved in HPV-unrelated pathway of carcinogenesis

Jul 7, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Verrucous Carcinoma
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