Verrucous Carcinoma



Verrucous Carcinoma


Elsa F. Velazquez, MD

Antonio L. Cubilla, MD










Cut section of a partial penectomy specimen shows a verruciform tumor with sharp bulbous base confined to the lamina propria.






Graphic of a verrucous carcinoma (yellow) highlights the papillary, spiky surface and well-demarcated base. Note the VC image, corpus spongiosum image, foreskin image, albuginea image, corpus cavernosum image, and urethra image.


TERMINOLOGY


Abbreviations



  • Verrucous carcinoma (VC)


Synonyms



  • Well-differentiated squamous cell carcinoma


Definitions



  • Extremely well-differentiated verruciform squamous cell carcinoma with bulbous deep borders and lack of koilocytosis


ETIOLOGY/PATHOGENESIS


Unknown Pathogenesis



  • Likely HPV-unrelated


  • Some cases are associated with lichen sclerosus


  • Tumor suppressor gene TP53 and its functional protein product p53 are believed to be involved in HPV-unrelated pathway of carcinogenesis

Jul 7, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Verrucous Carcinoma
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