Renal Tumors with Clear/Light-Staining Cytoplasm

Antibody

Clear Cell RCC

Chromophobe RCC

MITF/TFE Family Translocation-associated Carcinoma

Clear Cell Papillary RCC

Epithelioid Angiomyolipoma

CK7

−

+ (diffuse, occasionally patchy)

−

+ (diffuse, almost 100% tumor cells)

−

CD10

+ (membranous)

−/(rarely +)

+

(but often – in TFEB carcinoma)

−

−

Vimentin

+

− (rarely +)

−/+

+

−

Ksp-cadherin

−

+

−

ND

−

CD117

−

+ (diffuse, often peripheral membranous accentuation)

−

ND

−

AMACR

− (rarely focal +)

−

+ (usually)

−

−

EMA/MUC1

+

+

− (rarely focal +)

+

−

PAN-CK(AE1/AE3)

+

+

− (rarely focal +)

+

−

CAIX

+ (diffuse membranous)

− (+ perinecrotic areas)

− (+ in some cases)

+ (diffuse membranous)

−

TFE3/TFEB

−

−

+

−

−

Parvalbumin

−

+

−

−

−

Melan-A(MART-1)

−

−

+ in TFEB carcinoma, rarely + in TFE3

−

+

HMB-45

−

−

+ in TFEB carcinoma, rarely + in TFE3

−

+

MiTF

−

−

+ in TFEB carcinoma, rarely + in TFE3

−

+

Actin-sm

−

−

−

−

+/−

Renal Tumors with Papillary or Tubulopapillary Architecture

Antibody

Papillary RCC

Collecting Duct Carcinoma

Metanephric Adenoma

Mucinous Tubular and Spindle Cell Carcinoma

Clear Cell Papillary RCC

CK7

+

+

− (may be + in branching tubules or papillary structures)

+

+

CD10

+ (often luminal pattern)

−

−

−/+ (focal)

−

RCC

+

−

−

V

−/+

AMACR

+

−

−/+

+

−

EMA/MUC1

+

+

− (may be + in branching tubules or papillary structures)

+

+

WT1

−

−

+

−

−

HMCK(34βE12)

−

+/−

−

−/+

+

CD57

−

ND

+

−

ND

INI1

+

+ (lost in renal medullary carcinoma)

+

+

+

Ulex-1

−

+

−

−

ND

CAIX

− (+ perinecrotic areas and papillary tips)

−/+(perinecrotic area)

ND

ND

+

(V = Variable, ND = No Data)

Renal Tumors with Granular/Eosinophilic Cytoplasm

Antibody

Clear Cell RCC, Eosinophilic

Chromophobe RCC, Eosinophilic

Oncocytoma

MiTF/TFE Family Translocation-associated Carcinoma

Epithelioid Angiomyolipoma

Vimentin

+/−

− (rarely +)

−

−/+

+

CD117

−

+

+

−

−

Pax-2

+

− (rarely +)

+

V

−

RCC

+

−/+

−/+

+

−

CK7

−

+/−

−

−

−

CD10

+

−/+

+

+ in TFE3 carcinoma, often (−) in TFEB

−

Ksp-cadherin

−

+

+

V

−

Parvalbumin

−

+

+

ND

−

EpCAM/BER-EP4

V

+

− (occasionally focal or patchy +)

V

−

TFE3/TFEB

−

−

−

+

−

Melan-A(MART-1)

−

−

−

+ in TFEB carcinoma, rarely + in TFE3

+

HMB-45

−

−

−

+ in TFEB carcinoma, rarely + in TFE3

+

MiTF

−

−

−

+ in TFEB carcinoma, rarely + in TFE3

+

Actin-sm

−

−

−

−

+/−

HMCK(34βE12)

−

− (rarely focal +)

−

− (occasionally focal +)

−

EMA/MUC1

+

+ (occasionally only focal +)

+ (occasionally only focal +)

− (occasionally focal +)

−

CAIX

+

−

−

− (+ in some cases)

−