Squamous Cell Carcinoma, Usual Type

Squamous Cell Carcinoma, Usual Type

Antonio L. Cubilla, MD

Alcides Chaux, MD

Elsa F. Velazquez, MD

Gross photograph of a penile SCC image with an exoendophytic pattern of growth invades up to the corpus spongiosum image of glans but spares urethra image and corpus cavernosum image.

Tumor nests of well-differentiated usual SCC are composed of neoplastic cells with ample, eosinophilic and keratinized cytoplasm, distinctive cellular borders, and retained epithelial maturation.



  • Squamous cell carcinoma (SCC)


  • Conventional/typical SCC

  • Epidermoid carcinoma

  • SCC, not otherwise specified (NOS)


  • Invasive carcinoma with features of keratinization (intracellular keratin pearls and intracellular bridges)


Infectious Agents

  • Human papillomavirus (HPV) infection in about 1/4 of cases



  • Incidence

    • Most common histologic subtype of penile SCC (60-65%)

  • Age

    • Average: 58 years


  • Solid tumoral mass usually affecting glans

  • Ulceration, pain, bleeding, or erythema may be seen


  • Primary treatment is surgical

  • Penile-preserving therapy in low-grade superficial tumors

  • Radiotherapy as adjuvant or neoadjuvant therapy

  • Chemotherapy for advanced cases (irresectable primary tumor &/or regional involvement)

  • Inguinal lymphadenectomy according to risk group


  • Most important prognostic factors include

    • Histologic grade

    • Anatomic level of infiltration (pathologic stage)

    • Vascular, lymphatic, and perineural invasion

  • Recurrences in 1/4 of cases

  • Inguinal nodal metastases in 1/3 of patients


General Features

  • Most tumors affect glans

  • Tumors exclusive of foreskin are less common

  • Superficial spreading is predominant pattern of growth

  • Gross features are nondistinctive

  • Average size is 2-4.8 cm

Jul 7, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Squamous Cell Carcinoma, Usual Type
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