Basaloid Carcinoma



Basaloid Carcinoma


Antonio L. Cubilla, MD

Alcides Chaux, MD

Elsa F. Velazquez, MD










Low-power view of basaloid carcinoma depicts the typical highly infiltrative pattern of nests composed of poorly differentiated cells with retraction artifact image and intense stromal reaction image.






Basaloid SCC nests of poorly differentiated carcinoma are seen with retraction spaces image and central, abrupt foci of keratinization image. Keratinization is typically focal in the majority of cases.


TERMINOLOGY


Synonyms



  • Basaloid squamous cell carcinoma (SCC)


Definitions



  • Aggressive variant of nonkeratinizing SCC composed of small to intermediate-sized basaloid cells


ETIOLOGY/PATHOGENESIS


Infectious Agents



  • Most cases are associated with human papillomavirus (HPV)


  • Serotype 16 is most common


CLINICAL ISSUES


Epidemiology



  • Incidence



    • 10-14% of all penile SCC


  • Age



    • Average = 52-54 years at presentation


Presentation



  • Large, ulcerated, nonexophytic mass


  • 1/2 to 2/3 of patients have positive inguinal nodes at diagnosis


Treatment



  • Surgical approaches



    • Deep tumors are treated with total penectomy and bilateral groin dissection


    • Tumors confined to superficial corpus spongiosum may be treated with partial penectomy


  • Adjuvant therapy



    • Chemotherapy for advanced cases


  • Radiation



    • Selected cases with superficial erectile tissue invasion


Prognosis



  • Local recurrence seen in 1/3 of cases


  • Regional metastases present in > 1/2 of patients


  • High cancer-specific mortality

Jul 7, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Basaloid Carcinoma
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