Basaloid Carcinoma

Basaloid Carcinoma

Antonio L. Cubilla, MD

Alcides Chaux, MD

Elsa F. Velazquez, MD

Low-power view of basaloid carcinoma depicts the typical highly infiltrative pattern of nests composed of poorly differentiated cells with retraction artifact image and intense stromal reaction image.

Basaloid SCC nests of poorly differentiated carcinoma are seen with retraction spaces image and central, abrupt foci of keratinization image. Keratinization is typically focal in the majority of cases.



  • Basaloid squamous cell carcinoma (SCC)


  • Aggressive variant of nonkeratinizing SCC composed of small to intermediate-sized basaloid cells


Infectious Agents

  • Most cases are associated with human papillomavirus (HPV)

  • Serotype 16 is most common



  • Incidence

    • 10-14% of all penile SCC

  • Age

    • Average = 52-54 years at presentation


  • Large, ulcerated, nonexophytic mass

  • 1/2 to 2/3 of patients have positive inguinal nodes at diagnosis


  • Surgical approaches

    • Deep tumors are treated with total penectomy and bilateral groin dissection

    • Tumors confined to superficial corpus spongiosum may be treated with partial penectomy

  • Adjuvant therapy

    • Chemotherapy for advanced cases

  • Radiation

    • Selected cases with superficial erectile tissue invasion


  • Local recurrence seen in 1/3 of cases

  • Regional metastases present in > 1/2 of patients

  • High cancer-specific mortality

Jul 7, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Basaloid Carcinoma
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