Carcinoma Cuniculatum



Carcinoma Cuniculatum


Antonio L. Cubilla, MD

Alcides Chaux, MD

Elsa F. Velazquez, MD










Cut section of a partial penectomy specimen shows a carcinoma cuniculatum. Note the deep tumoral invagination following the tunica albuginea and involving the corpus cavernosum.






Low-power view of a cut section shows carcinoma cuniculatum. Note the endophytic burrowing channels image and the deep pseudocystic space filled with keratin image.


TERMINOLOGY


Abbreviations



  • Carcinoma cuniculatum (CC)


Synonyms



  • Squamous cell carcinoma, hybrid verrucous carcinoma


Definitions



  • Distinct variant of verrucous carcinoma characterized by deep burrowing growth pattern mimicking rabbit burrows (cuniculi)


  • Represents hybrid (mixed) verrucous carcinoma with unique growth pattern


ETIOLOGY/PATHOGENESIS


Pathogenesis



  • Unknown


  • Likely not HPV-related


CLINICAL ISSUES


Epidemiology



  • Incidence



    • Very rare


    • Few cases described in literature


  • Age



    • Mean: 77 years


Site



  • Usually affects glans and extends to coronal sulcus and foreskin


Presentation



  • Large, papillomatous tumors with “cobblestone” appearance


Treatment



  • Surgery


Prognosis



  • Good prognosis


  • No reported metastases

Jul 7, 2016 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Carcinoma Cuniculatum
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