Conjunctival Nevus With Prominent Epithelial CystsConjunctival melanocytic nevi (50%) can exhibit numerous epithelial-lined cysts located within the lesion, as seen here under scanning magnification. This is a useful finding, supporting…
Primarily solid Primarily cystic Solid and cystic • Classically, does not connect to epidermis and is deep-seated • Solid areas composed of varying proportion of Clear cells Poroid cells Squamoid cells Rarely…
Clinical Photograph of PoromaClinical photograph shows a traumatized poroma on the lower back of an adult male, which presented as an irritated polypoid lesion. Poroma With Squamoid FeaturesLow magnification of…
Typically show hyperchromatic-staining nuclei with small nucleoli Cytoplasm with prominent melanin pigmentation • Atypical Reed nevus Often larger, more cellular lesions Increased mitotic activity, especially in junctional component Top Differential Diagnoses…
Autosomal dominant disease due to mutations in mismatch repair genes MLH1, MSH2, MSH6 Multiple sebaceous tumors including sebaceous adenomas, less likely carcinomas and sebaceomas Clinical Issues • Rare tumors; typically occur…
Malignant epithelial tumor of squamous keratinocytes Etiology/Pathogenesis • Most cases are related to UV radiation • Previous radiation therapy implicated in some cases; usually associated with more aggressive SCC Clinical Issues • Often…
4-6% of Caucasian adults > 50 years of age • Deep fibromatosis 2.40-4.43 new cases per 100,000 persons/year • Recurrences common for both superficial and deep fibromatoses, but deaths only from deep…
Other locations are less frequent • Usually solitary Multicentric tumors can occur • Some cases may be associated with viral warts (plantar lesions) • Verrucous carcinoma (VC) may arise in setting of longstanding…
Multicentricity at presentation likely represents locoregional metastases • Treatment: Wide surgical excision with negative margins • Indolent clinical course in majority of cases • Metastases in 20-30% • Overall mortality rate of 10-20% High-risk…
Superficial folliculocystic structures and calcifications Deeper infiltrative-appearing cords and small islands in densely fibrotic stroma Top Differential Diagnoses • Basal cell carcinoma • Microcystic adnexal carcinoma • Trichoblastoma • Trichoadenoma • Sebaceoma Clinical Photograph of…
