Herpesviruses Herpes simplex 1 and 2 Varicella-zoster Epstein-Barr Cytomegalovirus Human herpesvirus 6 Enteroviruses Poliovirus Coxsackievirus Echovirus Numbered enteroviruses Parechoviruses Human parechovirus 1–14 Arboviruses See Table 48.2 Childhood illness associated Measles…
Clinical use General assay characteristics Specific clinical applications Diagnosis Rapid turnaround time thereby facilitating targeted antiviral therapy Highly specific for the pathogen of interest More sensitive than conventional methods such…
Test Method Target Specimen volume a Range Amplicor HIV-1 Monitor® version 1.5 (Roche Diagnostics Indianapolis, IN) RT-PCR HIV-1 gag gene Standard 200 μl 400–750,000 copies/mL Ultrasensitive 500 μl 50–100,000 copies/mL…
Figure 20.1 Proposed mechanism for HLA-B*5701 abacavir hypersensitivity Australia was one of the earliest countries to introduce routine HLA-B*5701 screening and results from the prospective study that was conducted between…
© Springer International Publishing Switzerland 2016Debra G.B. Leonard (ed.)Molecular Pathology in Clinical Practice10.1007/978-3-319-19674-9_33 33. Breast Cancer Carolyn Mies1 (1) Genomic Health Inc., 301 Penobscot Drive, Redwood City, CA 94063, USA Carolyn Mies Email: cmies@genomichealth.com Abstract…
Gene Study 1 (%) Study 2 (%) Study 3 a (%) SDHB 16 (8.4) 24 (4.8) 38 (24.7) SDHC 2 (1.1) 4 (0.8) 2 (1.3) SDHD 3 (1.6) 47 (9.4)…
Skin cancer type Associated syndromes Cutaneous basal cell carcinoma Basal cell nevus syndrome (BCNS) Bazex syndrome Rombo syndrome Brooke-Spiegler syndrome Muir-Torre syndrome Xeroderma pigmentosum Squamous cell carcinoma Xeroderma pigmentosum Ferguson-Smith…
© Springer International Publishing Switzerland 2016Debra G.B. Leonard (ed.)Molecular Pathology in Clinical Practice10.1007/978-3-319-19674-9_26 26. Von Hippel-Lindau Disease Catherine A. Stolle1 (1) Department of Pathology and Laboratory Medicine, The Children’s Hospital of Philadelphia, ARC 714G, 34th and…
© Springer International Publishing Switzerland 2016Debra G.B. Leonard (ed.)Molecular Pathology in Clinical Practice10.1007/978-3-319-19674-9_23 23. Familial Adenomatous Polyposis and Turcot and Peutz–Jeghers Syndromes Kandelaria M. Rumilla1 (1) Department of Laboratory Medicine and Pathology, Laboratory Genetics, Mayo Clinic,…
© Springer International Publishing Switzerland 2016Debra G.B. Leonard (ed.)Molecular Pathology in Clinical Practice10.1007/978-3-319-19674-9_22 22. Inherited Breast Cancer Rachel Michaelson-Cohen1, 2, Rachel Beeri2, Eliahu Golomb3 and Ephrat Levy-Lahad1, 2 (1) Hebrew University Medical School, Jerusalem, Israel (2) Medical Genetics…
