Figure 61.1 Comparison of forward-phase and reverse-phase protein microarrays. (a) Forward-phase microarray. Capture antibodies are first immobilized on the slide surface. These immobilized antibodies are used to capture the antigens…
Figure 6.1 Common types of chromosome abnormalities detected by standard chromosome analysis (G-banded karyotyping). (a) Aneuploidy, defined as the loss or gain of an entire chromosome, shown as trisomy 21….
Type Cytogenetic change(s) Genes affected Pathway type CML t(9;22) BCR–ABL1 TK growth +8, del17p (CE) PV, PMF, ET XY/XX JAK2 Cytokine receptors +9, +1/1q (CE) CEL/MPN-U XY/XX FIP1L1–PDGFRA RTK t(8p11;var)…
Amsterdam Criteria II There should be at least three relatives with an HNPCC-associated cancer (CRC, cancer of the endometrium, small bowel, ureter, or renal pelvis) One should be a first-degree…
Figure 12.1 FGFR-associated syndromic conditions Table 12.1 FGFR1, –2, and –3 genes Gene OMIM Chromosomal location Gene organization FGFR1 *136350 8p11.23-p11.22 18 exons, 17 coding FGFR2 *176943 10q26.13 18 exons,…
Tumor type Heritable retinoblastoma Nonheritable retinoblastoma Eyes affected Bilateral in 90–95 % of cases Unilateral in 100 % of cases Unilateral in remaining cases Age of onset Usually < 1…
Figure 32.1 Approximate prevalence of identified “driver mutations” in unselected pulmonary adenocarcinoma. While many of these alterations are typically seen in isolation, others, such as PIK3CA, are often seen concurrently…
Marker Indication 1p/19q deletion Oligodendroglioma diagnosis and prognosis Prediction of oligodendroglioma therapeutic response Confirmation of an oligodendroglial component in oligoastrocytomas MGMT promoter methylation Response of glioblastoma to alkylating drugs (temozolomide)…
Figure 4.1 Common pedigree symbols, definitions, and abbreviations. From Bennett R, French K, Resta R, Doyle D. Standardized human pedigree nomenclature: update and assessment of the recommendations of the national…
Virus: RTI and CAP Bacteria: RTI and CAP Bacteria: VAP and HAP Adenovirus (ADV) Bordetella pertussis and Bordetella parapertussis Acinetobacter spp., Human bocavirus (HBoV)a Chlamydophila pneumoniae Corynebacterium spp. Coronavirus (CoV)…
