VASCULAR TUMORS 12.1      Hemangiomas 12.2      Hemangioendothelioma 12.3      Kaposi Sarcoma 12.4      Angiosarcoma   12.1 Hemangiomas Hemangiomas represent benign proliferations of blood vessels. They occur in both the superficial and deep soft tissues, as well as…

SMALL ROUND BLUE CELL TUMORS 19.1      Ewing Sarcoma and Primitive Neuroectodermal Tumor 19.2      Lymphoma of Bone 19.3      Plasmacytoma 19.4      Mesenchymal Chondrosarcoma   19.1 Ewing Sarcoma and Primitive Neuroectodermal Tumor Primitive neuroectodermal tumor (PNET) was…

SMALL ROUND BLUE CELL TUMORS 9.1      Embryonal Rhabdomyosarcoma 9.2      Alveolar Rhabdomyosarcoma 9.3      Desmoplastic Small Round Cell Tumor 9.4      Extrarenal Rhabdoid Tumor 9.5      Melanotic Neuroectodermal Tumor of Infancy   9.1 Embryonal Rhabdomyosarcoma Embryonal rhabdomyosarcoma (ERMS) represents…

GIANT CELL-RICH TUMORS 10.1      Plexiform Fibrohistiocytic Tumor 10.2      Tenosynovial Giant Cell Tumors 10.3      Giant Cell Tumor of Soft Tissue   10.1 Plexiform Fibrohistiocytic Tumor Plexiform fibrohistiocytic tumor (PFHT) is a very unusual, distinctive…

PLEOMORPHIC SOFT TISSUE TUMORS 13.1      Pleomorphic Hyalinizing Angiectatic Tumor of Soft Parts 13.2      Pleomorphic Liposarcoma 13.3      Pleomorphic Myogenic Sarcomas (Rhabdomyosarcoma and Leiomyosarcoma) 13.4      Intimal Sarcoma 13.5      Undifferentiated/Pleomorphic Sarcoma   13.1 Pleomorphic Hyalinizing Angiectatic Tumor of…

GIANT CELL-RICH LESIONS 17.1      Langerhans Cell Histiocytosis (Eosinophilic Granuloma) 17.2      Giant Cell Lesion of Small Bones (Giant Cell Reparative Granuloma) 17.3      Giant Cell Tumor of Bone   17.1 Langerhans Cell Histiocytosis (Eosinophilic Granuloma)…

SOFT TISSUE TUMORS WITH INFLAMMATION 11.1      Angiomatoid Fibrous Histiocytoma 11.2      Myxoinflammatory Fibroblastic Sarcoma 11.3      Inflammatory Myofibroblastic Tumor 11.4      IgG4-Related Diseases   11.1 Angiomatoid Fibrous Histiocytoma Angiomatoid fibrous histiocytoma (AFH) is a rare tumor of…

CYSTIC LESIONS 20.1      Aneurysmal Bone Cyst 20.2      Simple Bone Cyst   20.1 Aneurysmal Bone Cyst A neurysmal bone cyst (ABC) is a benign lesion of bone that accounts for about 2% of…

PRINCIPLES OF DIAGNOSIS 2.1      Specimen Type and Procurement 2.2      Ancillary Testing 2.3      Tumor Grading and Staging   2.1 Specimen Type and Procurement For the most part, the purpose of the biopsy specimen is…

INTRODUCTION “Sarcoma” is a term derived from a Greek word, which translates as “fleshy growth.” Sarcomas are defined as deriving from cells of mesodermal origin including fat, connective tissues, tendon,…