General Principles
General Principles The science of psychopharmacotherapy continues to rapidly expand, creating both an opportunity and a challenge. As the neurosciences facilitate the development of new psychotropics, the art of applying…
Cytomegaloviruses
Cytomegaloviruses Edward S. Mocarski Jr Thomas Shenk Paul D. Griffiths Robert F. Pass Introduction Human cytomegalovirus (HCMV) is a ubiquitous virus infection with worldwide distribution. The virus is the most…
Herpesviridae
Herpesviridae Philip E. Pellett Bernard Roizman Who made the world I cannot tell; ‘Tis made, and here I am in hell. My hand, though now my knuckles bleed, I never…
Circoviridae
Circoviridae Xiang-Jin Meng History The prototype circovirus, porcine circovirus (PCV), was first reported in 1974 as papovavirus-like and picornavirus-like particles in a contaminated porcine kidney cell line PK-15.106 The name…
Parvoviridae
Parvoviridae Kenneth I. Berns Colin R. Parrish Introduction and History Parvoviruses are small, nonenveloped viruses with a linear, single-strand DNA (ssDNA) genome of about 5,000 bases. The family Parvoviridae (Table…
Adenoviruses
Adenoviruses William S.M. Wold Michael G. Ison History During attempts to establish tissue culture lines from tonsils and adenoidal tissue surgically removed from children, Rowe and colleagues613 recognized that a…
Adenoviridae
Adenoviridae Arnold J. Berk Adenoviruses were first isolated and characterized in 1953 by two groups who were searching for the etiologic agents of acute respiratory infections.134,283 The two isolated viruses…
Human Immunodeficiency Viruses: Replication
Human Immunodeficiency Viruses: Replication Eric O. Freed Malcolm A. Martin Introduction In the late 1970s and early 1980s, previously healthy patients with symptoms of immunologic dysfunction sought advice and treatment…
Foamy Viruses
Foamy Viruses Axel Rethwilm Dirk Lindemann The name foamy virus (FV) was coined in the 1950s to acknowledge the spontaneous emergence of the typical foamy cytopathic effect (CPE) produced in…
Papillomaviruses
Papillomaviruses Peter M. Howley John T. Schiller Douglas R. Lowy The papillomaviruses (PVs) comprise a group of nonenveloped epitheliotropic DNA viruses that induce benign lesions of the skin (warts) and…
