Figure 15.1ASTM D 6940-04 Segregation tester (with the top slide gate open and the powder flow from the mass flow hopper down to the funnel flow hopper). Fifty-milliliter glass beakers…
Figure 3.1PCcaps overall length and dimensions showing locking ring. (Courtesy of Capsugel.) Shen and Zhong [5] studied the bioavailability of atorvastatin in beagle dogs using SMEDDS consisting excipients such as…
14.1 where η is the Newtonian viscosity (mPa·s), σ is the shear stress (Pa), and γ˙ is the rate of shear (s−1). Newtonian fluids obey Equation 14.1; that is, there…
Figure 4.1Photograph of the Technophar capsule manufacturing machine. Hard capsule shell manufacturing remained almost exclusively in the United States from the 1880s until after the Second World War. Eli Lilly…
Figure 5.1Sorption isotherm data (absorption and desorption) of gelatin and HPMC (Vcaps® Plus) capsules stored at different RH values. (Courtesy of Capsugel.) The mechanical resistance and stiffness of two-piece capsules…
Figure 13.1Equilibrium moisture content of empty gelatin capsule shells stored at different relative humidities for 2 weeks at 20°C. (Reprinted from Adv Drug Del Rev, 60, Cole ET, Cade D,…
Figure 7.1A comparison of the original and modified pins of a Harro Hofliger KFM/3 capsule filling machine. (From Moolchandani V. Functionality and Performance of Different Lactose Grades in Capsule Filling:…
Figure 2.1Capsule shells being formed on mold pins. Figure 2.2Dried capsule shells on mold pins just before removal. After formation, the capsule shells can be printed to improve identification. Printing…
Figure 1.1Diagrammatic ternary phase diagram for studying the relationship between oil, water and surfactant for self-emulsifying lipid-based drug delivery systems. (Adapted from JB Cannon, MA Long. Emulsions, microemulsions, and lipid-based…
html xmlns=”http://www.w3.org/1999/xhtml” xmlns:epub=”http://www.idpf.org/2007/ops”> 11Scale-Up and Transfer of Hard Shell Formulations across Machine Types Larry L. Augsburger and Michael Levin Introduction Scaling Up within the Same Design and Operating Principle Regulatory…
