Adenoid Cystic Carcinoma
Only a few cases have metastasized, usually to lymph nodes and lungs Macroscopic • Usually a few centimeters, can be up to 8 cm Microscopic • Composed of infiltrative lobules, islands, and…
Digital Fibromatosis (Infantile Digital Fibromatosis)
No nuclear β-catenin labeling but cytoplasmic labeling common • Inclusions show granular &/or filamentous features by EM • Cytoplasmic filaments extend onto inclusions Infantile Digital Fibromatosis/Inclusion Body FibromatosisClinical examination of infantile digital…
Cutaneous Ciliated Cyst
Cutaneous müllerian cyst Eccrine cutaneous ciliated cyst Etiology/Pathogenesis • Müllerian (paramesonephric) heterotopia • Metaplasia of sweat gland epithelium Clinical Issues • Cutaneous müllerian cyst: Typically affects limbs of young female patients • Eccrine cutaneous…
Cutaneous Myxoma and Angiomyxoma
a.k.a. NAME (nevi, atrial myxomas, myxoid neurofibromas, and ephelides) and LAMB (lentigines, atrial myxomas, and blue nevi) syndromes If patient has multiple cutaneous myxomas, should consider Carney complex Clinical Issues…
Bronchogenic Cyst
Less commonly: Lateral, thyroid, or subcutaneous • M:F = 4:1 • Presents with airway compression, dysphagia, or infection, or may be asymptomatic • Complete surgical excision is treatment of choice • Excellent long-term clinical…
Trichofolliculoma
May also represent later stage/regressing variant of trichofolliculoma, but is typically dermal-based tumor with prominent sebaceous glands • Dilated pore of Winer Cystically dilated follicle that communicates with overlying epidermis • Trichoepithelioma…
Squamomelanocytic Tumor
Predominantly composed of atypical squamous cells, with scattered melanocytes – Melanocytes Of low density Single, not nested Dendritic shaped Nuclei not atypical • Pseudoepitheliomatous hyperplasia associated with malignant melanoma Keratinocytes in hyperplastic…
Retiform Hemangioendothelioma
More common in children • Composite hemangioendothelioma (HE) Composed of at least 2 distinct HE types • Kaposi sarcoma • Angiosarcoma Retiform Hemangioendothelioma at Low MagnificationLow-magnification examination of a retiform hemangioendothelioma (RHE) shows…
Multicentric Reticulohistiocytosis
SCR presents as single papular or nodular cutaneous lesion GCR is characterized by eruption of multiple small cutaneous lesions • Juvenile xanthogranuloma Typically single lesion occurring in children but can be…
Papillary Eccrine Adenoma
Evidence of apocrine glandular differentiation • Aggressive digital papillary adenocarcinoma Larger nodular tumor with ductal structures More cellular and shows infiltrative features • Metastatic adenocarcinoma Cytologic atypia and mitoses usually prominent Diagnostic…
