Papillary Eccrine Adenoma

 Evidence of apocrine glandular differentiation



• Aggressive digital papillary adenocarcinoma
image Larger nodular tumor with ductal structures

image More cellular and shows infiltrative features

• Metastatic adenocarcinoma
image Cytologic atypia and mitoses usually prominent




Diagnostic Checklist




• Dermal-based adnexal tumor with variably dilated eccrine ducts

image
Papillary Eccrine Adenoma
Low-power examination shows a dermal adnexal tumor with variably sized ductal and glandular spaces associated with a fibrous stroma.


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Papillary Eccrine Adenoma at Higher Magnification
On high magnification, the glands show low-cuboidal eccrine cells image and areas with cribriforming and papillary projection of variable complexity image. (Courtesy J. McNiff, MD.)

image
Papillary Eccrine Adenoma at High Magnification
High magnification shows uniform, small cuboidal cells lining the glands and forming papillary projections image. (Courtesy J. McNiff, MD.)

image
Immunohistochemistry for p63
p63 immunohistochemistry shows strong staining of the peripheral myoepithelial cell layer, consistent with a benign tumor. (Courtesy J. McNiff, MD.)


TERMINOLOGY


Abbreviations




• Papillary eccrine adenoma (PEA)


Synonyms




• Tubulopapillary hidradenoma with eccrine differentiation


Definitions




• Rare benign adnexal tumor with evidence of eccrine derivation/differentiation
image In the past, many cases with apocrine features were included in this category

image However, most authorities now separate PEAs from tubular apocrine adenomas

Apr 24, 2017 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Papillary Eccrine Adenoma
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