Lymphoepithelioma-Like Carcinoma of Skin


Lymphoepithelioma-Like Carcinoma of the Skin
High magnification of lymphoepithelioma-like carcinoma of the skin (LELCS) shows a prominent lymphohistiocytic infiltrate obscuring a background of large, undifferentiated epithelioid-appearing cells image.



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Low Magnification of LELCS
This is an example of LELCS at low magnification showing large, irregular epithelial islands surrounded by a very dense inflammatory infiltrate.

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High Magnification of LELCS
LELCS at high magnification shows islands of atypical basaloid-appearing epithelial cells image surrounded by a dense mixed acute and chronic inflammatory infiltrate.

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Immunohistochemistry for p63 in LELCS
Immunohistochemical stain for p63 shows diffuse nuclear staining image of the epithelial cells, which are in islands surrounded by inflammatory cells.


TERMINOLOGY


Abbreviations




• Lymphoepithelioma-like carcinoma of skin (LELCS)


Definitions




• Poorly differentiated carcinoma, most likely variant of squamous cell carcinoma (SCC), with prominent inflammatory infiltrate mimicking lymphoepithelioma-like carcinoma of nasopharynx


ETIOLOGY/PATHOGENESIS


Unknown




• No proven relationship with Epstein-Barr virus (EBV), unlike nasopharyngeal lymphoepitheliomas


CLINICAL ISSUES


Epidemiology




• Incidence
image Extremely rare variant of SCC; < 70 cases reported to date

• Age
image Typically occurs in elderly patients

• Sex
image M > F


Site




• Most common in head and neck region


Presentation




• Nodular erythematous lesion

May 13, 2017 | Posted by in PATHOLOGY & LABORATORY MEDICINE | Comments Off on Lymphoepithelioma-Like Carcinoma of Skin
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