High magnification of lymphoepithelioma-like carcinoma of the skin (LELCS) shows a prominent lymphohistiocytic infiltrate obscuring a background of large, undifferentiated epithelioid-appearing cells .
![image](https://i0.wp.com/basicmedicalkey.com/wp-content/uploads/2017/05/image03455.jpeg?w=960)
This is an example of LELCS at low magnification showing large, irregular epithelial islands surrounded by a very dense inflammatory infiltrate.
![image](https://i0.wp.com/basicmedicalkey.com/wp-content/uploads/2017/05/image03456.jpeg?w=960)
LELCS at high magnification shows islands of atypical basaloid-appearing epithelial cells
![image](https://i0.wp.com/basicmedicalkey.com/wp-content/uploads/2017/05/image03457.jpeg?w=960)
![image](https://i0.wp.com/basicmedicalkey.com/wp-content/uploads/2017/05/image03458.jpeg?w=960)
Immunohistochemical stain for p63 shows diffuse nuclear staining
![image](https://i0.wp.com/basicmedicalkey.com/wp-content/uploads/2017/05/image03459.jpeg?w=960)
CLINICAL ISSUES
Epidemiology
Treatment
• Surgical approaches
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