Composed of enlarged cells with abundant clear to vacuolated-appearing cytoplasm • Chondroid melanoma Malignant epithelioid cells associated with prominent myxochondroid-appearing matrix • Osteoid melanoma Malignant epithelioid cells associated with prominent osteoid-appearing material…
Conjunctival Melanoma Presenting as Pigmented PatchClinical image shows an expansile pigmented patch at the limbus and adjacent to the iris . Bulbar conjunctiva close to the limbus is the most…
Embryonal, alveolar, pleomorphic, and epithelioid types of RMS have been described as primary cutaneous tumors Clinical Issues • Very rare Cutaneous metastases or secondary involvement of skin by deep primary must…
Clinical PhotographPhotograph shows a medium-sized infantile hemangioma on the face of a female infant. Most of these lesions are located in the head and neck region. (Courtesy J. Hall, MD.)…
Conjunctival Nevus With Prominent Epithelial CystsConjunctival melanocytic nevi (50%) can exhibit numerous epithelial-lined cysts located within the lesion, as seen here under scanning magnification. This is a useful finding, supporting…
Primarily solid Primarily cystic Solid and cystic • Classically, does not connect to epidermis and is deep-seated • Solid areas composed of varying proportion of Clear cells Poroid cells Squamoid cells Rarely…
Clinical Photograph of PoromaClinical photograph shows a traumatized poroma on the lower back of an adult male, which presented as an irritated polypoid lesion. Poroma With Squamoid FeaturesLow magnification of…
Typically show hyperchromatic-staining nuclei with small nucleoli Cytoplasm with prominent melanin pigmentation • Atypical Reed nevus Often larger, more cellular lesions Increased mitotic activity, especially in junctional component Top Differential Diagnoses…
Autosomal dominant disease due to mutations in mismatch repair genes MLH1, MSH2, MSH6 Multiple sebaceous tumors including sebaceous adenomas, less likely carcinomas and sebaceomas Clinical Issues • Rare tumors; typically occur…
