KEY CONCEPTS Complex physiology surrounds the process of fertilization and pregnancy progression. Drug characteristics and physiologic changes modify drug pharmacokinetics during pregnancy, including changes in absorption, protein binding,…
KEY CONCEPTS Chronic kidney disease (CKD) results in minimal alterations in the absorption or bioavailability of most drugs. The volume of distribution (VD) of many drugs is increased…
Erectile Dysfunction Mary Lee KEY CONCEPTS The incidence of erectile dysfunction is low in men younger than 40 years of age. The incidence increases as men age, likely…
Disorders of Sodium and Water Homeostasis Katherine Hammond Chessman and Gary R. Matzke KEY CONCEPTS Blood volume and plasma osmolality are tightly regulated in the human body because…
KEY CONCEPTS Breast cancer is usually diagnosed in the early stages when it is a highly curable malignancy. Local therapy of early-stage breast cancer consists of modified radical…
KEY CONCEPTS Millions of Americans have osteoarthritis (OA). OA prevalence increases with age, with women more commonly affected than men. Contributors to OA are systemic (age, genetics, hormonal…
Diabetes Mellitus Curtis L. Triplitt, Thomas Repas, and Carlos A. Alvarez KEY CONCEPTS Diabetes mellitus (DM) is a group of metabolic disorders of fat, carbohydrate, and protein metabolism…
Viral Hepatitis Paulina Deming KEY CONCEPTS Hepatitis A is transmitted via the fecal–oral route. Transmission is most likely to occur through travel to countries with high rates of…
