Adrenergic Pharmacology Nidhi Gera, Ehrin J. Armstrong, and David E. Golan INTRODUCTION & CASE BIOCHEMISTRY AND PHYSIOLOGY OF ADRENERGIC FUNCTION Catecholamine Synthesis, Storage, and Release Reuptake and Metabolism of Catecholamines…
INTRODUCTION Our tissues are exposed on a daily basis to xenobiotics—foreign substances that are not naturally found in the body. Most drugs are xenobiotics that are used to modulate bodily…
Drug Transporters Baran A. Ersoy and Keith A. Hoffmaster INTRODUCTION & CASE UPTAKE AND EFFLUX TRANSPORTERS Uptake Transporters Organic Anion-Transporting Polypeptide (OATP) Family Organic Anion Transporter (OAT) Family Organic Cation…
INTRODUCTION Modern pharmacologic agents are used to treat or control diseases that range from hypertension to human immunodeficiency virus (HIV) infection. In many cases, the same drug regimens are used…
The results in Figure 4.1 can be displayed graphically by plotting the log concentration versus response (Figure 4.2). Figure 4.2 Log concentration–response curves for cholinesters. Questions 1. The responses are…
According to the Law of Mass Action, the value of the dissociation constant (Kd) could be derived as follows: (2.2) It was fully appreciated at the time that Kd is…
Particular care must be to ensure that all the units are the same. For example, if 10 μL of a 1 mg/mL solution is added to 20 mL organ bath,…
To count the number of live cells in a suspension, the following procedure is followed: The haemocytometer is cleaned with alcohol and dried using tissue paper and lens tissue. The…
where the molar extinction coefficient of TNB is 1.36 × 104 L/mol/cm. This is the absorbance of a 1 M solution in a 1 cm light path. The total volume…
Elevated Plus Maze (Neophobia) Test The test apparatus consists of two open arms (45 cm×15 cm) and two enclosed arms at 180° to each other. The entire maze was made…
