Chapter 1 Clinical Chemistry, Molecular Diagnostics, and Laboratory Medicine David E. Bruns, M.D., Edward R. Ashwood, M.D. and Carl A. Burtis, Ph.D. Clinical chemists, clinical biochemists, chemical pathologists, medical technologists,…
Figure 16-1 Pedigree of a family with an autosomal recessive condition. The probability of being a carrier is shown beneath each individual symbol in the pedigree. In contrast to single-gene disorders, the…
Figure 10-1 The effect of recombination on the origin of various portions of a chromosome. Because of crossing over in meiosis, the copy of the chromosome the boy (generation III) inherited from…
Fortunately, the factorial terms are always the same in the numerator and denominator of the likelihood ratio, and therefore they cancel each other out and can be ignored. If θ…
Figure 6-8 The process of sex determination and development: establishment of chromosomal sex at fertilization; commitment to the male or female pathway of gonadal differentiation; sex-specific differentiation of internal and external…
Figure 11-5 Scanning electron micrographs of red cells from a patient with sickle cell disease. A, Oxygenated cells are round and full. B, The classic sickle cell shape is produced only when…
The wild-type allele is denoted by uppercase R, a mutant allele by lowercase r. As seen in the table, when both parents of an affected person are carriers, their children’s…
*The values of a, b, c, and d are derived from a random sample of the population, divided into those with and without the susceptibility genotype, and then examined for…
Figure 12-16 Pseudohypertrophy of the calves due to the replacement of normal muscle tissue with connective tissue and fat in an 8-year-old boy with Duchenne muscular dystrophy. See Sources & Acknowledgments….
