Identity Assessment
Chapter 41 Identity Assessment Thomas M. Williams, M.D., Howard J. Baum, Ph.D., Victor W. Weedn, M.D., J.D. and Malek Kamoun, M.D., Ph.D. Identity testing exploits variations present within the human…
Clinical Utility of Laboratory Tests
Chapter 3 Clinical Utility of Laboratory Tests Edward R. Ashwood, M.D. and David E. Bruns, M.D.* A vast majority of medical decisions rely on laboratory testing. Clinicians often ask which…
Evidence-Based Laboratory Medicine
Chapter 4 Evidence-Based Laboratory Medicine Christopher P. Price, Ph.D., F.R.S.C., F.R.C.Path., Patrick M.M. Bossuyt, Ph.D. and David E. Bruns, M.D. This chapter expands upon the “Principles of Laboratory Medicine.” We…
Toxic Metals
Chapter 36 Toxic Metals Thomas P. Moyer, Ph.D. Metals have been recognized as toxins for centuries. For example, arsenic (As) poisoning was a favored way to dethrone royalty in the…
Specimen Collection and Processing
Chapter 7 Specimen Collection and Processing Doris M. Haverstick, Ph.D., D.A.B.C.C. and Amy R. Groszbach, M.E.D., M.L.T., M.B.(A.S.C.P.)C.M.* Proper collection, identification, processing, storage, and transport of common sample types associated…
Genomes and Nucleic Acid Alterations
Chapter 38 Genomes and Nucleic Acid Alterations Carl T. Wittwer, M.D., Ph.D. and Noriko Kusukawa, Ph.D. Molecular diagnostics focuses on medically important sequence variations within a background of complex genomic…
Plasma Nucleic Acids
Chapter 45 Plasma Nucleic Acids Y.M. Dennis Lo, M.A., D.M., D.Phil., F.R.C.P.(Lond. & Edin.), F.R.C.Path., F.R.S., and Rossa W.K. Chiu, M.B.B.S., Ph.D., F.H.K.A.M.(Pathology), F.R.C.P.A. With the notable exception of virology,…
Enzymes of the Red Blood Cell
Chapter 23 Enzymes of the Red Blood Cell Wouter W. van Solinge, Ph.D. and Richard van Wijk, Ph.D. Erythrocytes perform a variety of functions, the most important being the binding,…
Nucleic Acid Isolation
Chapter 39 Nucleic Acid Isolation Rossa W.K. Chiu, M.B.B.S., Ph.D., F.H.K.A.M.(Pathology), F.R.C.P.A. and Y.M. Dennis Lo, M.A., D.M., D.Phil., F.R.C.P.,(Lond. & Edin.), F.R.C.Path., F.R.S.* Many of the key advances in…
Automation in the Clinical Laboratory
Chapter 19 Automation in the Clinical Laboratory James C. Boyd, M.D. and Charles D. Hawker, Ph.D., M.B.A., F.A.C.B. The term automation has been applied in clinical chemistry to describe the…
