Antiviral Agents
Antiviral Agents Donald M. Coen Douglas D. Richman Overview Medical Importance of Antiviral Drugs and Barriers to Their Development Viruses are a leading cause of disease and death worldwide. Although…
Epidemiology
Epidemiology Neal Nathanson William J. Moss Basic Definitions and Methods Epidemiology deals with the occurrence of diseases in populations. Historically, epidemics of viral disease were recognized long before their causal…
Virus Evolution
Virus Evolution Edward C. Holmes Although Charles Darwin preempted many of the great questions in evolutionary biology, he wrote little about viral infections. Of course, viruses were not formally identified…
Pathogenesis of Viral Infection
Pathogenesis of Viral Infection Mark T. Heise Herbert W. Virgin Introduction to Viral Pathogenesis Viral pathogenesis is the series of steps that occurs when a virus infects the host. Viruses…
Adaptive Immune Response to Viral Infections
Adaptive Immune Response to Viral Infections Thomas J. Braciale Young S. Hahn Dennis R. Burton Introduction Viruses have been part of human ecology since the human species first evolved on…
Innate Responses to Viral Infections
Innate Responses to Viral Infections Akiko Iwasaki Ruslan Medzhitov The innate immune system provides a universal form of host protection from infectious diseases. It detects the presence of pathogens using…
Viruses, Cell Transformation, and Cancer
Viruses, Cell Transformation, and Cancer Daniel DiMaio Hung Fan General Principles of Viral Transformation In 1908, Ellerman and Bang143 reported that cell-free filtrates from chickens with leukemia could transmit the…
Virus Assembly
Virus Assembly Eric Hunter Virus assembly, a key step in the replication cycle of any virus, involves a process in which chemically distinct macromolecules are transported, often through different pathways,…
Viral Replication Strategies
Viral Replication Strategies Sean Whelan Introduction Replication of genetic information is the single most distinctive characteristic of living organisms, and nowhere in the biosphere is replication accomplished with greater economy…
Virus Entry and Uncoating
Virus Entry and Uncoating Ari Helenius Viral particles have a single mission: to transport the viral genome from an infected host cell to a noninfected host cell and to deliver…
