Hairy Cell Leukemia Variant
Hairy Cell Leukemia Variant Roberto N. Miranda, MD Key Facts Terminology Hairy cell leukemia variant (HCL-v) Mature B-cell neoplasm involving peripheral blood, bone marrow, and spleen Resembles classical HCL but…
Diffuse Large B-cell Lymphoma Arising in the Spleen
Diffuse Large B-cell Lymphoma Arising in the Spleen Roberto N. Miranda, MD Key Facts Terminology Primary DLBCL of spleen is rare Involvement of splenic hilar lymph nodes and bone marrow…
Splenic Marginal Zone Lymphoma
Splenic Marginal Zone Lymphoma Roberto N. Miranda, MD Key Facts Terminology Splenic marginal zone lymphoma (SMZL), splenic B-cell marginal zone lymphoma (2008 WHO), splenic lymphoma with circulating villous lymphocytes (SLVL)…
Mantle Cell Lymphoma
Mantle Cell Lymphoma Roberto N. Miranda, MD Key Facts Etiology/Pathogenesis CCND1-IGH/t(11;14)(q13;q32) resulting in Cyclin-D1 overexpression in most cases Clinical Issues MCL is nodal-based disease but extranodal sites of involvement are…
Splenic Inflammatory Pseudotumor
Splenic Inflammatory Pseudotumor Roberto N. Miranda, MD Key Facts Terminology Splenic inflammatory pseudotumor (IPT) Clinical Issues Age: 19-87 years (median: 53 years) Rare in children Slight female predominance Excision is…
Primary Cutaneous Follicle Center Lymphoma
Primary Cutaneous Follicle Center Lymphoma Roberto N. Miranda, MD Key Facts Terminology Lymphoma arising in skin composed of follicular center cells Subset of cases appear to be clinically and genetically…
Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Roberto N. Miranda, MD Key Facts Terminology CLL/SLL is neoplasm of small B lymphocytes that typically involves peripheral blood (PB), bone marrow (BM), lymph nodes,…
Nodal Follicular Lymphoma
Nodal Follicular Lymphoma C. Cameron Yin, MD, PhD Key Facts Terminology B-cell neoplasm composed of germinal center B cells (centrocytes and centroblasts) Etiology/Pathogenesis Overexpression of antiapoptotic Bcl-2 due to t(14;18)…
Splenic Diffuse Red Pulp Small B-cell Lymphoma
Splenic Diffuse Red Pulp Small B-cell Lymphoma Roberto N. Miranda, MD Key Facts Terminology Abbreviation: SDRP SBCL Provisional entity in 2008 WHO classification Clinical Issues Low level of lymphocytosis Splenomegaly;…
Inflammatory Pseudotumor-like Follicular Dendritic Cell Tumor
Inflammatory Pseudotumor-like Follicular Dendritic Cell Tumor Roberto N. Miranda, MD Key Facts Terminology Inflammatory pseudotumor-like follicular dendritic cell tumor (IPT-FDCT) Considered variant of follicular dendritic cell sarcoma Classification is controversial…
