INTRODUCTION Over the past decade, the US Food and Drug Administration (FDA) has approved approximately 260 new therapeutics, including 220 new molecular entities (small molecules) and 42 biotherapeutics (generally, recombinant…
Pharmacology of Drugs of Abuse Peter R. Martin and Sachin Patel INTRODUCTION & CASE DEFINITIONS MECHANISMS OF TOLERANCE, DEPENDENCE, AND WITHDRAWAL Tolerance Dependence and Withdrawal MECHANISMS OF SUBSTANCE USE DISORDERS…
Pharmacology of Volume Regulation Hakan R. Toka and Seth L. Alper INTRODUCTION & CASE PHYSIOLOGY OF VOLUME REGULATION Determinants of Intravascular Volume Volume Sensors Volume Regulators Renin-Angiotensin-Aldosterone System Natriuretic Peptides…
INTRODUCTION This chapter presents endocrine pharmacology relevant to both the male and female reproductive tracts. Although men and women differ in their hormonal profiles, androgens and estrogens are both under…
Pharmacology of Parasitic Infections Louise C. Ivers and Edward T. Ryan INTRODUCTION MALARIAL PLASMODIA & CASES 1–2 Physiology of Malarial Plasmodia Life Cycle Heme Metabolism Electron Transport Chain Pharmacology of…
Pharmacology of Bone Mineral Homeostasis David M. Slovik and Ehrin J. Armstrong INTRODUCTION & CASE PHYSIOLOGY OF BONE MINERAL HOMEOSTASIS Structure of Bone Mineral Balance Regulation of Bone Remodeling Hormonal…
Principles of Cellular Excitability and Electrochemical Transmission Elizabeth Mayne, Lauren K. Buhl, and Gary R. Strichartz INTRODUCTION & CASE CELLULAR EXCITABILITY Ohm’s Law Ion Channels Channel Selectivity, the Nernst Equation,…
Pharmacology of Cancer: Signal Transduction David A. Barbie and David A. Frank INTRODUCTION & CASE BIOCHEMISTRY OF INTERCELLULAR AND INTRACELLULAR SIGNAL TRANSDUCTION Growth Factors and Growth Factor Receptors Intracellular Signal…
Pharmacology of Immunosuppression Elizabeth A. Brezinski, Lloyd B. Klickstein, and April W. Armstrong INTRODUCTION & CASE PATHOPHYSIOLOGY Transplantation Solid Organ Rejection Graft-Versus-Host Disease (GVHD) Autoimmunity PHARMACOLOGIC CLASSES AND AGENTS Inhibitors…
INTRODUCTION Cholinergic pharmacology is centered on the properties of the first identified neurotransmitter, acetylcholine (ACh). The functions of cholinergic pathways are diverse; generally, they involve the neuromuscular junction (NMJ), the…
