Basicmedical Key

Acute Myeloid Leukemia Diane C. Farhi GENERAL FEATURES Nomenclature Acute leukemia arising from myeloid cells has been variously referred to as myeloblastic, myelocytic, and myeloid, with little, if any, clarification…

Effects of Therapy Diane C. Farhi Numerous therapeutic agents are used in treating hematolymphoid disorders, and their effects are diverse. This section focuses on morphologic changes observed in the peripheral…

Other Nonneoplastic Conditions Diane C. Farhi ACQUIRED NONCLONAL MYELODYSPLASIA Acquired nonclonal myelodysplasia (NMD) is undoubtedly underrecognized. It closely mimics constitutional hematopoietic disorders and clonal myelodysplastic syndromes and may easily be…

Infectious Disease and Related Topics Diane C. Farhi The incidence of marrow involvement, variety of organisms, and frequency of multiple infections have greatly increased in recent years because of the…

Systemic Disease Diane C. Farhi ENDOCRINE AND RENAL DISORDERS Hyperthyroidism Hyperthyroidism has been associated with diverse hematologic effects (1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12,…

Stromal Tissue and Extracellular Space Diane C. Farhi The stromal tissue of the bone marrow consists of adipose tissue, fibrous tissue, blood vessels, trabecular bone, and the extracellular space. The…

Lymphocytes and Plasma Cells Diane C. Farhi LYMPHOPENIA Peripheral Blood Lymphopenia Lymphopenia is a common finding in the peripheral blood, and results from numerous different pathways (1, 2, 3, 4)….

Platelets and Megakaryocytes Thuy-Lieu Thi Vo Diane C. Farhi This section is concerned with benign, acquired processes of platelets and megakaryocytes in the peripheral blood and bone marrow. The differential…

Mast Cells Diane C. Farhi This chapter concerns constitutional, childhood-onset, and reactive mastocytosis. Clonal disorders of mastocytes are discussed in later chapters, with myeloproliferative neoplasms, myelodysplastic syndromes, and acute myeloid…