Nonhematolymphoid Neoplasms Diane C. Farhi PERIPHERAL BLOOD AND NONHEMATOLYMPHOID NEOPLASMS Nonhematolymphoid tumors occasionally present with overt peripheral blood disease resembling acute leukemia (Table 28.1) (1, 2, 3, 4, 5, 6,…
Natural Killer-Cell Neoplasms Diane C. Farhi Natural killer (NK)-cell neoplasms are rare, therefore the accumulation of data has been relatively slow compared to other hematolymphoid malignancies. The WHO classified these…
T-Cell Neoplasms Diane C. Farhi The T-cell neoplasms are relatively rare compared to B-cell neoplasms, but they nevertheless consist of many different entities. In this chapter, we have included the…
Plasma Cell and Related Neoplasms Diane C. Farhi Plasma cell neoplasms comprise a wide spectrum of disease (Tables 25.1 and 25.2). The entities discussed below differ widely in clinical presentation,…
Hodgkin Lymphoma Diane C. Farhi GENERAL FEATURES Hodgkin lymphoma (HL) is a B-cell neoplasm characterized by neoplastic cells—Reed-Sternberg cells and their variants—in a prominent inflammatory and fibrous background (1, 2,…
B-Cell Neoplasms Diane C. Farhi B-cell neoplasms are a heterogeneous group of clinicopathologic entities, ranging from indolent to highly aggressive (Table 23.1). Those composed predominantly of mature small B-cells may…
Histiocytic Dendritic Cell and Neoplasms Diane C. Farhi Tumors of dendritic cells and histiocytes have been recently reclassified (2008) by the World Health Organization (WHO) (Table 22.1; see Appendix A…
Myeloproliferative and Related Neoplasms Diane C. Farhi GENERAL FEATURES Definition and Classification Myeloproliferative neoplasms (MPN) are primarily characterized by increased peripheral blood cell counts, increased bone marrow cellularity, and preservation…
Myelodysplastic Syndromes Diane C. Farhi GENERAL FEATURES Definition and Classification Myelodysplastic syndromes (MDS) are a group of clonal disorders of hematopoietic stem cells, characterized by dysplastic morphology, cytogenetic aberrations, and—in…
Precursor Lymphoid Neoplasms Diane C. Farhi GENERAL FEATURES Nomenclature New precursor lymphoid neoplasms include “solid” tumors or lymphoblastic lymphoma, and “liquid” tumors or acute lymphoblastic leukemia (ALL). Lymphoblastic lymphoma may…
