Anti-Cancer Drugs for the Nonspecialist

Apr 8, 2017 by in PHARMACY Comments Off on Anti-Cancer Drugs for the Nonspecialist

Phase nonspecificPOBone marrow suppressionPlatinum CompoundsCarboplatinGeneric onlyPhase nonspecificIVBone marrow suppressionCisplatinGeneric onlyPhase nonspecificIVNephrotoxicityOxaliplatinEloxatinPhase nonspecificIVPeripheral neuropathyANTIMETABOLITESFolic Acid AnalogsMethotrexateRheumatrex, TrexallS-phase specificIV, IM, PO, ITBone marrow suppression, mucositisPemetrexedAlimtaS-phase specificIVBone marrow suppressionPralatrexateFolotynS-phase specificIVBone marrow suppression, mucositisPyrimidine…

read more

Drugs for Asthma and Chronic Obstructive Pulmonary Disease

Apr 8, 2017 by in PHARMACY Comments Off on Drugs for Asthma and Chronic Obstructive Pulmonary Disease

Figure 60.1 Allergen-induced inflammation and bronchospasm in asthma.  Pathophysiology of Chronic Obstructive Pulmonary Disease Symptoms of COPD result largely from two pathologic processes: chronic bronchitis and emphysema. In most cases, both…

read more

Antidysrhythmic Drugs

Apr 8, 2017 by in PHARMACY Comments Off on Antidysrhythmic Drugs

Figure 41.1 Cardiac conduction pathways.  SA Node Under normal circumstances, the SA node serves as the pacemaker for the heart. Pacemaker activity results from spontaneous phase 4 depolarization (see later). Because…

read more

Drugs Acting on the Renin-Angiotensin-Aldosterone System

Apr 8, 2017 by in PHARMACY Comments Off on Drugs Acting on the Renin-Angiotensin-Aldosterone System

Figure 36.1 Regulation of blood pressure by the renin-angiotensin-aldosterone system. In addition to the mechanisms depicted, angiotensin II can raise blood pressure by (1) acting on the distal nephron to promote reabsorption…

read more

Drugs for Diabetes Mellitus

Apr 8, 2017 by in PHARMACY Comments Off on Drugs for Diabetes Mellitus

Insulin Preparations Insulin lispro (short duration, rapid acting) Regular insulin (short duration, slower acting) NPH insulin (intermediate duration) Insulin glargine (long duration) Biguanide Metformin Sulfonylurea Glyburide Meglitinide (Glinide) Repaglinide Thiazolidinedione…

read more

Pharmacokinetics, Pharmacodynamics, and Drug Interactions

Apr 8, 2017 by in PHARMACY Comments Off on Pharmacokinetics, Pharmacodynamics, and Drug Interactions

Figure 4.1 The four basic pharmacokinetic processes. Dotted lines represent membranes that must be crossed as drugs move throughout the body.  Application of Pharmacokinetics in Pharmacotherapeutics By applying knowledge of pharmacokinetics to…

read more

Drugs for the Eye

Apr 8, 2017 by in PHARMACY Comments Off on Drugs for the Eye

Figure 84.1 Anatomy of the normal eye.  Pathophysiology and Treatment Overview   Patient Education Glaucoma • It is important to take the prescribed medications according to schedule. If days are skipped…

read more

Antiviral Agents I

Apr 8, 2017 by in PHARMACY Comments Off on Antiviral Agents I

Advise patients to apply the drug with a finger cot or rubber glove to avoid viral transfer to other body sites or other people. Inform patients with herpes simplex genitalis…

read more

Drugs Affecting Calcium Levels and Bone Mineralization

Apr 8, 2017 by in PHARMACY Comments Off on Drugs Affecting Calcium Levels and Bone Mineralization

Figure 59.1 Bone remodeling cycle. A, Quiescent bone with lining cells covering the surface. B, Resorption of old bone by multinucleated osteoclasts. C, Osteoblasts migrate to the absorption site. D, Osteoblasts deposit…

read more

Drugs for Epilepsy

Apr 8, 2017 by in PHARMACY Comments Off on Drugs for Epilepsy

*Drug possesses more than one mechanism of action Suppression of Sodium Influx Before discussing AED actions, we need to review sodium channel physiology. Neuronal action potentials are propagated by influx…

read more
Premium Wordpress Themes by UFO Themes